F9 and GGCX

Data Source:
HPRD (in vivo)

		F9	GGCX
Description		coagulation factor IX	gamma-glutamyl carboxylase
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Golgi Lumen Plasma Membrane Collagen-containing Extracellular Matrix Extracellular Exosome	Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane
	Molecular Function	Endopeptidase Activity Serine-type Endopeptidase Activity Calcium Ion Binding Protein Binding	Gamma-glutamyl Carboxylase Activity Vitamin Binding
	Biological Process	Proteolysis Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Blood Coagulation Blood Coagulation, Intrinsic Pathway Zymogen Activation	Cellular Protein Modification Process Blood Coagulation Peptidyl-glutamic Acid Carboxylation
Pathways		Extrinsic Pathway of Fibrin Clot Formation Intrinsic Pathway of Fibrin Clot Formation Gamma-carboxylation of protein precursors Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus Removal of aminoterminal propeptides from gamma-carboxylated proteins Defective factor IX causes thrombophilia Defective cofactor function of FVIIIa variant Defective F9 variant does not activate FX Defective F9 secretion Defective F9 activation Defective gamma-carboxylation of F9	Gamma-carboxylation of protein precursors Gamma-carboxylation of protein precursors Defective gamma-carboxylation of F9
Drugs		Antihemophilic factor, human recombinant Menadione TTP889 Turoctocog alfa Kappadione Coagulation factor VII human Antihemophilic factor human Emicizumab Lonoctocog alfa Moroctocog alfa Turoctocog alfa pegol	Coagulation factor VIIa Recombinant Human Coagulation Factor IX (Recombinant) Glutamic acid Menadione Phylloquinone Anisindione Kappadione Coagulation Factor IX Human
Diseases		Hemophilia; Hemophilia A (HEMA); Hemophilia B (HEMB); von Willebrand disease (VWD)	Pseudoxanthoma elasticum, including: Pseudoxanthoma elasticum (PXE); Pseudoxanthoma elasticum-like disorder with multiple coagulation factor deficiency Combined deficiency of vitamin K-dependent clotting factors (VKCFD)
GWAS		Venous thromboembolism ( 31676865)	Coronary artery disease ( 29212778 26343387) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) High light scatter reticulocyte count ( 32888494) Myocardial infarction ( 26343387) Prostate cancer ( 21743467) Triglyceride levels ( 32203549)
Interacting Genes		5 interacting genes: F2 F7 F8 GGCX LRP1	7 interacting genes: BGLAP F10 F2 F7 F9 PROC SRPK2
Entrez ID		2158	2677
HPRD ID		02385	00665
Ensembl ID		ENSG00000101981	ENSG00000115486
Uniprot IDs		P00740	P38435
PDB IDs		1CFH 1CFI 1EDM 1IXA 1MGX 1NL0 1RFN 2WPH 2WPI 2WPJ 2WPK 2WPL 2WPM 3KCG 3LC3 3LC5 4WM0 4WMA 4WMB 4WMI 4WMK 4WN2 4WNH 4YZU 4Z0K 4ZAE 5EGM 5F84 5F85 5F86 5JB8 5JB9 5JBA 5JBB 5JBC 5TNO 5TNT 5VYG 6MV4 6RFK 6X5J 6X5L 6X5P
Enriched GO Terms of Interacting Partners?
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