EZH1 and E2F6

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		EZH1	E2F6
Description		enhancer of zeste 1 polycomb repressive complex 2 subunit	E2F transcription factor 6
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleoplasm ESC/E(Z) Complex	Chromatin Nucleus Nucleoplasm MLL1 Complex RNA Polymerase II Transcription Regulator Complex
	Molecular Function	DNA Binding Chromatin Binding Transcription Corepressor Activity Histone-lysine N-methyltransferase Activity Nucleosomal Histone Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Protein Binding Protein Dimerization Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Remodeling Chromatin Silencing At Telomere Anatomical Structure Morphogenesis Hippocampus Development Heterochromatin Assembly Positive Regulation Of Transcription By RNA Polymerase II Histone H3-K27 Methylation	Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Negative Regulation Of G0 To G1 Transition
Pathways			G1/S-Specific Transcription Transcriptional Regulation by E2F6
Drugs		Tazemetostat
Diseases
GWAS		Height ( 31562340)	Diisocyanate-induced asthma ( 25918132) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Sudden cardiac arrest ( 21658281)
Interacting Genes		3 interacting genes: E2F6 EED ZMYND11	27 interacting genes: APP ARAF BMI1 BRDT CENPU DNMT1 DNMT3L DNTTIP1 E2F1 EPC1 EZH1 EZH2 HMG20B INO80B KRTAP10-7 NFYA PCGF6 PIK3R3 RING1 RYBP SMARCA4 TFDP1 TFDP2 ZBTB17 ZBTB32 ZFPM2 ZMYND11
Entrez ID		2145	1876
HPRD ID		03397	04251
Ensembl ID		ENSG00000108799	ENSG00000169016
Uniprot IDs		A0A0A0MSY9 Q92800	A0A0S2Z3K8 O75461 Q53YM3 Q6Q9Z5
PDB IDs
Enriched GO Terms of Interacting Partners?
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