ERBB4 and YES1

Data Source:
BioGRID (pull down)

		ERBB4	YES1
Description		erb-b2 receptor tyrosine kinase 4	YES proto-oncogene 1, Src family tyrosine kinase
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GO Annotations	Cellular Component	Extracellular Region Nucleus Nucleoplasm Mitochondrion Mitochondrial Matrix Cytosol Plasma Membrane Integral Component Of Plasma Membrane Basal Plasma Membrane Basolateral Plasma Membrane Receptor Complex Postsynaptic Membrane Glutamatergic Synapse GABA-ergic Synapse Integral Component Of Presynaptic Membrane Integral Component Of Postsynaptic Density Membrane	Golgi Apparatus Microtubule Organizing Center Cytosol Plasma Membrane Focal Adhesion Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Extracellular Exosome
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Epidermal Growth Factor Receptor Binding Protein Binding ATP Binding Protein Homodimerization Activity	Phosphotyrosine Residue Binding Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Signaling Receptor Binding Protein Binding ATP Binding Enzyme Binding Ion Channel Binding
	Biological Process	MAPK Cascade Neural Crest Cell Migration Positive Regulation Of Protein Phosphorylation Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organism Development Nervous System Development Synapse Assembly Heart Development Lactation Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Embryonic Pattern Specification Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Cell Migration Peptidyl-tyrosine Phosphorylation Central Nervous System Morphogenesis Olfactory Bulb Interneuron Differentiation Regulation Of Cell Migration Positive Regulation Of Kinase Activity ERBB2 Signaling Pathway Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Mitochondrial Fragmentation Involved In Apoptotic Process Cell Fate Commitment Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Protein Autophosphorylation Positive Regulation Of Protein Kinase B Signaling Positive Regulation Of Cardiac Muscle Cell Proliferation Mammary Gland Epithelial Cell Differentiation Mammary Gland Alveolus Development Cardiac Muscle Tissue Regeneration Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Epidermal Growth Factor Stimulus Positive Regulation Of Protein Localization To Cell Surface Regulation Of Cell Motility Negative Regulation Of Neuron Migration	Cellular Protein Modification Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Differentiation T Cell Costimulation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of Vascular Permeability Innate Immune Response Ephrin Receptor Signaling Pathway Leukocyte Migration
Pathways			Signaling by ERBB2 Signaling by SCF-KIT Signaling by SCF-KIT Regulation of KIT signaling FCGR activation PECAM1 interactions EPH-Ephrin signaling CD28 co-stimulation CTLA4 inhibitory signaling EPHB-mediated forward signaling EPHB-mediated forward signaling EPHA-mediated growth cone collapse EPHA-mediated growth cone collapse EPH-ephrin mediated repulsion of cells RUNX2 regulates osteoblast differentiation Regulation of signaling by CBL Regulation of signaling by CBL FCGR3A-mediated IL10 synthesis FCGR3A-mediated phagocytosis Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants
Drugs		Afatinib Fostamatinib Brigatinib Zanubrutinib	Dasatinib Fostamatinib
Diseases
GWAS		Adult body size ( 32376654) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Asthma (sex interaction) ( 24824216) Atrial fibrillation ( 30061737 29892015) BMI (adjusted for smoking behaviour) ( 28443625) BMI in non-smokers ( 28443625) Body mass index ( 28892062 25673413) Body mass index (change over time) ( 25133637) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Breast cancer ( 22452962) Coronary artery calcification ( 23870195) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Estimated glomerular filtration rate ( 31152163) Feeling fed-up ( 29500382) Feeling lonely ( 29500382) Glomerular filtration rate ( 29403010) Household income ( 31844048) Household income (MTAG) ( 31844048) Intelligence (MTAG) ( 29326435) Liver fibrosis in non-alcoholic fatty acid liver disease ( 31311600) Loneliness ( 31518406 29970889) Loneliness (MTAG) ( 29970889) Metabolite levels ( 23823483) Personality dimensions ( 23903073) Polycystic ovary syndrome ( 32289280 26416764) Positive urgency ( 30718321) QT interval (ambient particulate matter interaction) ( 28749367) Skin aging (microtopography measurement) ( 28502801) Sperm motility ( 29453196) Systolic blood pressure ( 30224653) Thyroxine levels ( 30843173) Total intracranial volume ( 31530798) Triiodothyronine levels ( 30843173) Type 1 diabetes nephropathy ( 23028342) Urate levels ( 31578528)	Diastolic blood pressure ( 29403010 30487518) Hypertension ( 30487518) Mean arterial pressure ( 29403010 30487518) PR interval in Tripanosoma cruzi seropositivity ( 24324551) Pulmonary function in asthmatics ( 23541324) Pursuit maintenance gain ( 29064472) Systolic blood pressure ( 30224653 29403010 30487518 30578418) Thyroid autoantibody positivity (anti-thyroglobulin (TgAb) and/or anti-thyroid peroxidase (TPOAb) levels) ( 31794020)
Interacting Genes		149 interacting genes: ABL1 ABL2 ADAM17 ALDOA ANKS1A ANKS1B BCAR3 BLK BTC CCN2 CD44 CDC25C CFL1 CRK DLG1 DLG2 DLG3 DLG4 DUSP10 DUSP14 DUSP16 DUSP18 DUSP19 DUSP21 DUSP6 EGFR ERBB2 ERBB3 EREG ERG28 FAM241B FES FGR FKBP1A GABARAPL2 GRAP2 GRB10 GRB2 GRB7 HBEGF HCK HDAC6 HSH2D ILKAP INPPL1 IRF2BP2 ITCH ITK LCK LCP2 LRRC7 LYN MATK MTMR2 MTMR6 MTMR9 MUC1 MUC4 NCK1 NCK2 NEDD4 NRG1 NRG2 NRG3 NRG4 NTRK2 PIK3R1 PIK3R2 PIK3R3 PIN4 PLCG1 PLCG2 PPM1A PPM1B PPM1F PRDX5 PRRG4 PTK6 PTPDC1 PTPN11 PTPN12 PTPN20 PTPN21 PTPN6 PTPN7 PTPRH PTPRR PTPRT RASA1 RNF41 RTN4 S100A11 SELENOK SH2B1 SH2B2 SH2B3 SH2D1A SH2D1B SH2D2A SH2D3C SH3BP2 SHB SHC1 SHC2 SHC3 SHC4 SHD SLA SLA2 SMIM20 SNAP91 SNTB2 SOCS1 SOCS2 SOCS3 SOCS5 SOCS6 SRC STAP1 STAT5A STAT5B STYX SYK SYNM TAB1 TAB2 TEC TFAP2C TGFA TMA7 TMEM134 TMEM14A TMEM230 TNS1 TNS2 TNS3 TNS4 TRO TVP23B TXK TXN VAV1 VAV2 VAV3 WWOX YAP1 YES1 ZAP70 ZNF532	98 interacting genes: ADAM12 ADAM15 AMOTL2 AR BCAR1 BECN1 BICD2 C1orf94 CARD9 CBL CBLB CBLC CCDC33 CD2AP CD36 CD46 CDH1 CDKN1B CEP57L1 CEP83 CHMP1A CPSF6 CRKL CSF1R DDIT4L DENND2C DES DLG4 DOK1 DOK2 DTX3 DVL2 EFS EGFR EPHB2 ERBB2 ERBB3 ERBB4 FASLG FGFR1 FLACC1 FLT1 FUNDC1 FXR1 FXR2 GAB1 GAS8 GFAP GP6 IKZF3 ITGB4 JAK2 JAKMIP1 KDR KHDRBS1 KIT LASP1 LIN7C MET MST1R NEDD4 NIF3L1 NPHS1 OGT PAK2 PDCD6IP PDGFRB PECAM1 PICK1 PIK3R3 PTEN PTK2 PTPRE PXN RASA1 RPL10 SH3GLB2 SKAP2 SLC9A3R1 SOCS2 SOCS3 SOCS7 SPRR2A SSBP3 STAP2 THAP1 TNK2 TP53BP2 TRAF2 TRAF6 TRIM5 TRPV4 TSGA10IP TYRO3 ZBTB8A ZC2HC1A ZNF438 ZNF512B
Entrez ID		2066	7525
HPRD ID		02767	01285
Ensembl ID		ENSG00000178568	ENSG00000176105
Uniprot IDs		Q15303	P07947
PDB IDs		2AHX 2L2T 2LCX 2R4B 3BBT 3BBW 3BCE 3U2P 3U7U 3U9U	2HDA
Enriched GO Terms of Interacting Partners?
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