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EPRS1 and MIR222
Data Source:
BioGRID
(unspecified method)
EPRS1
MIR222
Description
glutamyl-prolyl-tRNA synthetase 1
microRNA 222
Image
No pdb structure
GO Annotations
Cellular Component
Cytoplasm
Cytosol
Plasma Membrane
Membrane
Aminoacyl-tRNA Synthetase Multienzyme Complex
GAIT Complex
Ribonucleoprotein Complex
Extracellular Space
Extracellular Vesicle
Molecular Function
Glutamate-tRNA Ligase Activity
Proline-tRNA Ligase Activity
Protein Binding
ATP Binding
Zinc Ion Binding
RNA Stem-loop Binding
Identical Protein Binding
Protein Homodimerization Activity
GTPase Binding
MRNA Binding Involved In Posttranscriptional Gene Silencing
Biological Process
TRNA Aminoacylation For Protein Translation
Glutamyl-tRNA Aminoacylation
Prolyl-tRNA Aminoacylation
Negative Regulation Of Translation
Cellular Response To Insulin Stimulus
Protein-containing Complex Assembly
Cellular Response To Interferon-gamma
Regulation Of Long-chain Fatty Acid Import Into Cell
Positive Regulation Of Epithelial Cell Migration
Positive Regulation Of Epithelial To Mesenchymal Transition
Negative Regulation Of Angiogenesis
Negative Regulation Of Interleukin-21 Production
Gene Silencing By MiRNA
MiRNA Mediated Inhibition Of Translation
Negative Regulation Of Apoptotic Process
Negative Regulation By Host Of Viral Genome Replication
Positive Regulation Of Erythrocyte Differentiation
Positive Regulation Of Axon Regeneration
Negative Regulation Of Inflammatory Response
Positive Regulation Of Protein Kinase B Signaling
Positive Regulation Of Cardiac Muscle Cell Proliferation
Negative Regulation Of Cell Adhesion Molecule Production
Positive Regulation Of ERK1 And ERK2 Cascade
Positive Regulation Of Canonical Wnt Signaling Pathway
Negative Regulation Of Cytokine Production Involved In Inflammatory Response
Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle
Positive Regulation Of Schwann Cell Migration
Negative Regulation Of Hematopoietic Stem Cell Proliferation
Negative Regulation Of TRAIL-activated Apoptotic Signaling Pathway
Negative Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis
Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation
Negative Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell
Positive Regulation Of Schwann Cell Proliferation Involved In Axon Regeneration
Negative Regulation Of Cardiac Muscle Cell Differentiation
Pathways
Selenoamino acid metabolism
Cytosolic tRNA aminoacylation
tRNA modification in the nucleus and cytosol
Drugs
Glutamic acid
Proline
5'-O-(L-Prolylsulfamoyl)adenosine
5'-O-(L-Cysteinylsulfamoyl)adenosine
5'-O-(N-(Alanyl)sulfamoyl)adenosine
Diseases
GWAS
Interacting Genes
89 interacting genes:
AIMP2
ARL4D
CDC42
DUS2
DUX4
EEF1D
ESR1
HSP90AA1
IARS1
LINC01554
MIR1-1
MIR1-2
MIR106A
MIR106B
MIR107
MIR10B
MIR122
MIR128-1
MIR128-2
MIR138-1
MIR138-2
MIR140
MIR141
MIR143
MIR145
MIR155
MIR15A
MIR15B
MIR16-1
MIR16-2
MIR17
MIR18A
MIR18B
MIR199A1
MIR199A2
MIR19A
MIR19B1
MIR19B2
MIR200A
MIR200B
MIR200C
MIR205
MIR206
MIR20A
MIR20B
MIR21
MIR214
MIR221
MIR222
MIR25
MIR29A
MIR29B1
MIR29B2
MIR29C
MIR31
MIR34A
MIR34B
MIR34C
MIR363
MIR429
MIR451A
MIR7-1
MIR7-2
MIR7-3
MIR9-1
MIR9-2
MIR9-3
MIR92A1
MIR92A2
MIR93
MIR98
MIRLET7A1
MIRLET7A2
MIRLET7A3
MIRLET7B
MIRLET7C
MIRLET7D
MIRLET7E
MIRLET7F1
MIRLET7F2
MIRLET7G
MIRLET7I
NEDD4
NELFCD
PTEN
RARS1
SUMO2
SYNCRIP
TAB1
75 interacting genes:
ADARB1
AIMP1
AIMP2
APOBEC3B
AQR
C1QBP
DARS1
DDX1
DDX21
DDX3X
DHX36
EDC4
EIF2AK2
EPRS1
ESRP1
FAM98A
FAM98B
FUS
G3BP2
HNRNPA0
HNRNPA1
HNRNPA2B1
HNRNPA3
HNRNPF
HNRNPH1
HNRNPH2
HNRNPH3
HNRNPK
HNRNPL
HNRNPM
HNRNPR
IGF2BP1
IGF2BP2
IGF2BP3
KNOP1
LARP7
LIN28A
LRPPRC
MATR3
MSI2
NONO
PDCD11
PLOD1
PRMT1
PTBP1
PTBP3
PUF60
PURA
QARS1
RBFOX2
RBM14
RBM4
RBMS2
RTCA
RTCB
SF3B1
SF3B2
SF3B3
SF3B4
SFPQ
SPOUT1
SUGP2
SYNCRIP
TAF15
TENT2
TRA2A
TRA2B
U2SURP
UPF1
UTP20
YBX1
YBX2
YBX3
ZFR
ZNF346
Entrez ID
2058
407007
HPRD ID
00703
Ensembl ID
ENSG00000136628
ENSG00000207725
Uniprot IDs
P07814
PDB IDs
1FYJ
4HVC
4K86
4K87
4K88
5A1N
5A34
5A5H
5BMU
5V58
5VAD
5Y6L
6IY6
Enriched GO Terms of Interacting Partners
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