ANKS6 and C5

Data Source:
BioGRID (two hybrid)

		ANKS6	C5
Description		ankyrin repeat and sterile alpha motif domain containing 6	complement C5
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GO Annotations	Cellular Component	Cytoplasm Ciliary Inversin Compartment	Extracellular Region Membrane Attack Complex Extracellular Space Extracellular Exosome
	Molecular Function	Protein Binding	Endopeptidase Inhibitor Activity Signaling Receptor Binding Protein Binding Chemokine Activity
	Biological Process	In Utero Embryonic Development Kidney Development Determination Of Left/right Symmetry Heart Development	Activation Of MAPK Activity In Utero Embryonic Development Chemotaxis Inflammatory Response Complement Activation, Alternative Pathway Complement Activation, Classical Pathway Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Vascular Endothelial Growth Factor Production Negative Regulation Of Macrophage Chemotaxis Negative Regulation Of Endopeptidase Activity Cytolysis Regulation Of Complement Activation Positive Regulation Of Chemokine Production Positive Regulation Of Angiogenesis Cell Chemotaxis
Pathways			Terminal pathway of complement Activation of C3 and C5 Peptide ligand-binding receptors G alpha (i) signalling events Regulation of Complement cascade
Drugs			Human immunoglobulin G Eculizumab Zinc Copper Ravulizumab Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases			Late complement pathway defects, including the following seven diseases: C5 deficiency; C6 deficiency; C7 deficiency; C8 alpha-chain deficiency; C8 beta-chain deficiency; C8 gamma-chain deficiency; C9 deficiency
GWAS		Body mass index ( 28892062)	Blood protein levels ( 30072576) Coronary artery disease ( 29212778) Hip circumference adjusted for BMI ( 25673412) Pulse pressure ( 27841878) Refractive error ( 32231278) Rheumatoid arthritis ( 30891314 24390342 20453842 19503088)
Interacting Genes		19 interacting genes: AGTRAP APP BCL2L2 BET1 C1GALT1 C5 EMD EMP1 IGFBP5 MARCHF5 PITPNC1 RTP2 SMIM1 STRIT1 STX7 TMEM120B TMEM60 VAMP4 VEZT	22 interacting genes: ANKS6 AQP6 C2 C3 C5AR1 C6 C7 C8B CPB2 CPLX4 CPN1 CREB3L1 EBP KEL KIR3DL3 LMNA MMGT1 NEMP1 PGRMC2 POU6F2 SSMEM1 VEZT
Entrez ID		203286	727
HPRD ID		18012	00405
Ensembl ID		ENSG00000165138	ENSG00000106804
Uniprot IDs		B3KXP1 Q68DC2	P01031 Q59GS8
PDB IDs		4NL9	1CFA 1KJS 1XWE 3CU7 3HQA 3HQB 3KLS 3KM9 3PRX 3PVM 4A5W 4E0S 4P39 4UU9 5B4P 5B71 5HCC 5HCD 5HCE 5I5K 6H03 6H04 6RPT
Enriched GO Terms of Interacting Partners?
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