C5 and CPN1

Data Source:
HPRD (in vitro)

		C5	CPN1
Description		complement C5	carboxypeptidase N subunit 1
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GO Annotations	Cellular Component	Extracellular Region Membrane Attack Complex Extracellular Space Extracellular Exosome	Extracellular Region Extracellular Space
	Molecular Function	Endopeptidase Inhibitor Activity Signaling Receptor Binding Protein Binding Chemokine Activity	Metallocarboxypeptidase Activity Protein Binding Zinc Ion Binding
	Biological Process	Activation Of MAPK Activity In Utero Embryonic Development Chemotaxis Inflammatory Response Complement Activation, Alternative Pathway Complement Activation, Classical Pathway Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Vascular Endothelial Growth Factor Production Negative Regulation Of Macrophage Chemotaxis Negative Regulation Of Endopeptidase Activity Cytolysis Regulation Of Complement Activation Positive Regulation Of Chemokine Production Positive Regulation Of Angiogenesis Cell Chemotaxis	Peptide Metabolic Process Bradykinin Catabolic Process Protein Processing Regulation Of Complement Activation Response To Glucocorticoid
Pathways		Terminal pathway of complement Activation of C3 and C5 Peptide ligand-binding receptors G alpha (i) signalling events Regulation of Complement cascade	Regulation of Complement cascade
Drugs		Human immunoglobulin G Eculizumab Zinc Copper Ravulizumab Zinc acetate Zinc chloride Zinc sulfate, unspecified form	Zinc ORE-1001 Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases		Late complement pathway defects, including the following seven diseases: C5 deficiency; C6 deficiency; C7 deficiency; C8 alpha-chain deficiency; C8 beta-chain deficiency; C8 gamma-chain deficiency; C9 deficiency
GWAS		Blood protein levels ( 30072576) Coronary artery disease ( 29212778) Hip circumference adjusted for BMI ( 25673412) Pulse pressure ( 27841878) Refractive error ( 32231278) Rheumatoid arthritis ( 30891314 24390342 20453842 19503088)	Blood protein levels ( 29875488 28240269 23696881) Creatine kinase levels ( 29403010) Dermatomyositis ( 27153935) Femoral neck bone mineral density ( 22504420) General cognitive ability ( 29844566) Heel bone mineral density ( 30598549) Height ( 20881960) Liver enzyme levels ( 18940312) Liver enzyme levels (alanine transaminase) ( 22001757) Mean reticulocyte volume ( 32888494)
Interacting Genes		22 interacting genes: ANKS6 AQP6 C2 C3 C5AR1 C6 C7 C8B CPB2 CPLX4 CPN1 CREB3L1 EBP KEL KIR3DL3 LMNA MMGT1 NEMP1 PGRMC2 POU6F2 SSMEM1 VEZT	6 interacting genes: C3 C5 CDC42 CLEC4G CPN2 KNG1
Entrez ID		727	1369
HPRD ID		00405	09120
Ensembl ID		ENSG00000106804	ENSG00000120054
Uniprot IDs		P01031 Q59GS8	P15169
PDB IDs		1CFA 1KJS 1XWE 3CU7 3HQA 3HQB 3KLS 3KM9 3PRX 3PVM 4A5W 4E0S 4P39 4UU9 5B4P 5B71 5HCC 5HCD 5HCE 5I5K 6H03 6H04 6RPT	2NSM
Enriched GO Terms of Interacting Partners?
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