TGFBR3 and DYNLT4

Data Source:
HPRD (two hybrid)

		TGFBR3	DYNLT4
Description		transforming growth factor beta receptor 3	dynein light chain Tctex-type 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Space Cytoplasm Integral Component Of Plasma Membrane External Side Of Plasma Membrane Cell Surface Extracellular Matrix Inhibin-betaglycan-ActRII Complex Receptor Complex Extracellular Exosome	Acrosomal Vesicle Nucleus Microtubule Organizing Center Axoneme Sperm Flagellum
	Molecular Function	Transforming Growth Factor Beta-activated Receptor Activity Type II Transforming Growth Factor Beta Receptor Binding Transforming Growth Factor Beta Receptor Binding Protein Binding Glycosaminoglycan Binding Heparin Binding Coreceptor Activity Fibroblast Growth Factor Binding PDZ Domain Binding SMAD Binding Activin Binding Transforming Growth Factor Beta Binding Transforming Growth Factor Beta Receptor Activity, Type III	Protein Binding Protein Phosphatase 1 Binding
	Biological Process	Angiogenesis Vasculogenesis Response To Hypoxia Epithelial To Mesenchymal Transition Liver Development Heart Morphogenesis Muscular Septum Morphogenesis Outflow Tract Morphogenesis Ventricular Compact Myocardium Morphogenesis Immune Response Transforming Growth Factor Beta Receptor Signaling Pathway Transforming Growth Factor Beta Receptor Complex Assembly Cell Migration Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway BMP Signaling Pathway Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Animal Organ Regeneration Response To Follicle-stimulating Hormone Response To Prostaglandin E Response To Luteinizing Hormone Intracellular Signal Transduction Regulation Of Protein Binding Regulation Of JNK Cascade Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of Cellular Component Movement Ventricular Cardiac Muscle Tissue Morphogenesis Cardiac Muscle Cell Proliferation Positive Regulation Of Cardiac Muscle Cell Proliferation Definitive Hemopoiesis Cardiac Epithelial To Mesenchymal Transition Definitive Erythrocyte Differentiation Heart Trabecula Formation Pathway-restricted SMAD Protein Phosphorylation Ventricular Septum Morphogenesis Epicardium-derived Cardiac Fibroblast Cell Development Vasculogenesis Involved In Coronary Vascular Morphogenesis Heart Trabecula Morphogenesis Secondary Palate Development Regulation Of ERK1 And ERK2 Cascade
Pathways
Drugs
Diseases
GWAS		Bone mineral density ( 19249006) Carotid plaque burden ( 28282560) Gestational age at birth (maternal effect) ( 28877031) Glaucoma (primary open-angle) ( 25861811) HDL cholesterol change in response to fenofibrate in statin-treated type 2 diabetes ( 28736931) Heel bone mineral density ( 30598549) HOMA-B (corrected for HOMA-IR) ( 30369944) Lung function (FEV1/FVC) ( 28166213 30804560) Lung function (FVC) ( 26635082 30804560) Multiple sclerosis ( 31604244) Optic disc area ( 25631615 31798171 28073927 21307088) Optic disc parameters ( 20548946) Optic disc size ( 31809533) Optic nerve measurement (cup-to-disc ratio) ( 28061514) Peak expiratory flow ( 30804560) Pulse pressure ( 30224653) QT interval (tricyclic/tetracyclic antidepressant use interaction) ( 28039329) Type 2 diabetes ( 23209189) Vertical cup-disc ratio ( 31798171 25241763 28073927) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)
Interacting Genes		13 interacting genes: ACVR2A ARRB2 DYNLT4 ENG GIPC1 INHA INHBA NRP1 SDC2 TGFB1 TGFB2 TGFB3 TGFBR2	7 interacting genes: ACVR2A ENG MDFI PPP1CA PPP1CC TGFBR2 TGFBR3
Entrez ID		7049	343521
HPRD ID		02846	15762
Ensembl ID		ENSG00000069702	ENSG00000188396
Uniprot IDs		A0A0A8KWK3 Q03167	Q5JR98
PDB IDs
Enriched GO Terms of Interacting Partners?
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