TGFBR3 and NRP1

Data Source:
BioGRID (pull down)

		TGFBR3	NRP1
Description		transforming growth factor beta receptor 3	neuropilin 1
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Space Cytoplasm Integral Component Of Plasma Membrane External Side Of Plasma Membrane Cell Surface Extracellular Matrix Inhibin-betaglycan-ActRII Complex Receptor Complex Extracellular Exosome	Semaphorin Receptor Complex Extracellular Space Early Endosome Cytosol Plasma Membrane Focal Adhesion Cell Surface Integral Component Of Membrane Axon Growth Cone Cytoplasmic Vesicle Mitochondrial Membrane Neuron Projection Neuronal Cell Body Receptor Complex Sorting Endosome
	Molecular Function	Transforming Growth Factor Beta-activated Receptor Activity Type II Transforming Growth Factor Beta Receptor Binding Transforming Growth Factor Beta Receptor Binding Protein Binding Glycosaminoglycan Binding Heparin Binding Coreceptor Activity Fibroblast Growth Factor Binding PDZ Domain Binding SMAD Binding Activin Binding Transforming Growth Factor Beta Binding Transforming Growth Factor Beta Receptor Activity, Type III	Vascular Endothelial Growth Factor-activated Receptor Activity GTPase Activator Activity Protein Binding Heparin Binding Coreceptor Activity Semaphorin Receptor Activity Growth Factor Binding Cytokine Binding Vascular Endothelial Growth Factor Binding Metal Ion Binding
	Biological Process	Angiogenesis Vasculogenesis Response To Hypoxia Epithelial To Mesenchymal Transition Liver Development Heart Morphogenesis Muscular Septum Morphogenesis Outflow Tract Morphogenesis Ventricular Compact Myocardium Morphogenesis Immune Response Transforming Growth Factor Beta Receptor Signaling Pathway Transforming Growth Factor Beta Receptor Complex Assembly Cell Migration Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway BMP Signaling Pathway Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Animal Organ Regeneration Response To Follicle-stimulating Hormone Response To Prostaglandin E Response To Luteinizing Hormone Intracellular Signal Transduction Regulation Of Protein Binding Regulation Of JNK Cascade Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of Cellular Component Movement Ventricular Cardiac Muscle Tissue Morphogenesis Cardiac Muscle Cell Proliferation Positive Regulation Of Cardiac Muscle Cell Proliferation Definitive Hemopoiesis Cardiac Epithelial To Mesenchymal Transition Definitive Erythrocyte Differentiation Heart Trabecula Formation Pathway-restricted SMAD Protein Phosphorylation Ventricular Septum Morphogenesis Epicardium-derived Cardiac Fibroblast Cell Development Vasculogenesis Involved In Coronary Vascular Morphogenesis Heart Trabecula Morphogenesis Secondary Palate Development Regulation Of ERK1 And ERK2 Cascade	Angiogenesis Branching Involved In Blood Vessel Morphogenesis Neuron Migration Positive Regulation Of Endothelial Cell Proliferation Sprouting Angiogenesis Cell Migration Involved In Sprouting Angiogenesis Outflow Tract Septum Morphogenesis Substrate-dependent Cell Migration, Cell Extension Signal Transduction Integrin-mediated Signaling Pathway Cell-cell Signaling Axon Guidance Response To Wounding Animal Organ Morphogenesis Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Smooth Muscle Cell Migration Nerve Development Retinal Ganglion Cell Axon Guidance Actin Cytoskeleton Reorganization Regulation Of Cdc42 Protein Signal Transduction Substrate Adhesion-dependent Cell Spreading Cellular Response To Hepatocyte Growth Factor Stimulus Endothelial Cell Chemotaxis Cellular Response To Vascular Endothelial Growth Factor Stimulus Neuropilin Signaling Pathway VEGF-activated Neuropilin Signaling Pathway Positive Regulation Of Phosphorylation Endothelial Cell Migration Positive Regulation Of GTPase Activity Viral Entry Into Host Cell Platelet-derived Growth Factor Receptor Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Hepatocyte Growth Factor Receptor Signaling Pathway Positive Regulation Of Axon Extension Involved In Axon Guidance Negative Regulation Of Axon Extension Involved In Axon Guidance Artery Morphogenesis Axon Extension Involved In Axon Guidance Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Chemotaxis Positive Regulation Of Filopodium Assembly Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Focal Adhesion Assembly Positive Regulation Of Cytokine Activity Axonogenesis Involved In Innervation Regulation Of Vesicle-mediated Transport Angiogenesis Involved In Coronary Vascular Morphogenesis Retina Vasculature Morphogenesis In Camera-type Eye Sympathetic Ganglion Development Positive Regulation Of ERK1 And ERK2 Cascade Semaphorin-plexin Signaling Pathway Commissural Neuron Axon Guidance Regulation Of Retinal Ganglion Cell Axon Guidance Endothelial Tip Cell Fate Specification Motor Neuron Migration Sympathetic Neuron Projection Extension Sympathetic Neuron Projection Guidance Basal Dendrite Development Basal Dendrite Arborization Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Neural Crest Cell Migration Involved In Autonomic Nervous System Development Semaphorin-plexin Signaling Pathway Involved In Neuron Projection Guidance Positive Regulation Of Retinal Ganglion Cell Axon Guidance Protein Localization To Early Endosome Positive Regulation Of Actin Cytoskeleton Reorganization
Pathways			Neurophilin interactions with VEGF and VEGFR Signaling by ROBO receptors Sema3A PAK dependent Axon repulsion SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion CRMPs in Sema3A signaling CRMPs in Sema3A signaling Signal transduction by L1 CHL1 interactions
Drugs
Diseases
GWAS		Bone mineral density ( 19249006) Carotid plaque burden ( 28282560) Gestational age at birth (maternal effect) ( 28877031) Glaucoma (primary open-angle) ( 25861811) HDL cholesterol change in response to fenofibrate in statin-treated type 2 diabetes ( 28736931) Heel bone mineral density ( 30598549) HOMA-B (corrected for HOMA-IR) ( 30369944) Lung function (FEV1/FVC) ( 28166213 30804560) Lung function (FVC) ( 26635082 30804560) Multiple sclerosis ( 31604244) Optic disc area ( 25631615 31798171 28073927 21307088) Optic disc parameters ( 20548946) Optic disc size ( 31809533) Optic nerve measurement (cup-to-disc ratio) ( 28061514) Peak expiratory flow ( 30804560) Pulse pressure ( 30224653) QT interval (tricyclic/tetracyclic antidepressant use interaction) ( 28039329) Type 2 diabetes ( 23209189) Vertical cup-disc ratio ( 31798171 25241763 28073927) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)	Apolipoprotein A1 levels ( 32203549) Blood protein levels ( 30072576 29875488) Brain morphology (MOSTest) ( 32665545) Coronary artery disease ( 29212778) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) HDL cholesterol levels ( 32203549) Migraine ( 27322543) Reticulocyte count ( 32888494) Schizophrenia ( 21682944) Small cell lung carcinoma ( 28604730) Tetralogy of Fallot ( 23297363)
Interacting Genes		13 interacting genes: ACVR2A ARRB2 DYNLT4 ENG GIPC1 INHA INHBA NRP1 SDC2 TGFB1 TGFB2 TGFB3 TGFBR2	23 interacting genes: FGF1 FGF2 FGF4 FGF7 FGFR1 FLT1 GIPC1 KDR L1CAM NRP2 PGF PLXNA1 PLXNB1 RPL27 SEMA3A SEMA3B SEMA3C SEMA3F TGFBR1 TGFBR2 TGFBR3 VEGFA VEGFB
Entrez ID		7049	8829
HPRD ID		02846	03642
Ensembl ID		ENSG00000069702	ENSG00000099250
Uniprot IDs		A0A0A8KWK3 Q03167	A8K9V7 O14786 Q59F20 Q68DN3 Q6AWA9 Q6X907
PDB IDs			1KEX 2QQI 2QQM 2QQN 3I97 4DEQ 4RN5 5C7G 5IJR 5IYY 5J1X 5JGI 5JGQ 5JHK 5L73 6FMC 6FMF 7JJC
Enriched GO Terms of Interacting Partners?
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