ARHGAP27 and SH3KBP1

Data Source:
HPRD (in vitro, two hybrid, in vivo)

		ARHGAP27	SH3KBP1
Description		Rho GTPase activating protein 27	SH3 domain containing kinase binding protein 1
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GO Annotations	Cellular Component	Cytoplasm Membrane	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Cell-cell Junction Focal Adhesion Endocytic Vesicle Cytoplasmic Vesicle Membrane Neuron Projection Synapse
	Molecular Function	GTPase Activator Activity SH3 Domain Binding	Protein Binding SH3 Domain Binding
	Biological Process	Receptor-mediated Endocytosis Signal Transduction Regulation Of GTPase Activity Positive Regulation Of GTPase Activity	Endocytosis Apoptotic Process Cytoskeleton Organization Actin Filament Organization Cell-cell Signaling Axon Guidance Regulation Of Cell Shape Cell Migration Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of B Cell Activation Membrane Organization
Pathways		Rho GTPase cycle	EGFR downregulation Negative regulation of MET activity Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Reelin signalling pathway InlB-mediated entry of Listeria monocytogenes into host cell Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406) Asthma ( 30929738) Asthma (childhood onset) ( 30929738) Asthma onset (childhood vs adult) ( 30929738) Brain morphology (MOSTest) ( 32665545) Cognitive function ( 28093568) Cortical surface area (global PC1) ( 32198502) General cognitive ability ( 29844566) General factor of neuroticism ( 30867560) Hemoglobin levels ( 32327693) Male-pattern baldness ( 28196072) Mean platelet volume ( 32888494) Neuroticism ( 29255261) Parkinson's disease ( 28892059) Refractive error ( 32231278) Systemic lupus erythematosus ( 29848360)	Platelet count ( 32888494)
Interacting Genes		3 interacting genes: CDC42 RAC1 SH3KBP1	58 interacting genes: ABI2 ANKS1A ARAP3 ARHGAP27 ASAP1 ASAP2 BCAR1 BHLHB9 BLNK BMPR1B CAPZA1 CBL CBLB CCDC57 CCDC88B CD2 CYSRT1 DENND2A GGN GRB2 HCK HIVEP1 INPP5D ITSN2 KPRP KRTAP6-3 LZTS2 MVB12A NEDD4 NELFA PAK2 PDCD6 PDCD6IP PIK3CA PIK3R1 PNMA5 POLR2K PSMA3 SEPTIN2 SEPTIN6 SH3BP2 SH3GL2 SH3GL3 SH3GLB1 SH3GLB2 SHKBP1 SOS1 SPRY2 STAP1 SYNJ1 TAF6 TJP2 TP53BP2 UBB UBC UBE2I ZBTB7B ZNF219
Entrez ID		201176	30011
HPRD ID		12477	02301
Ensembl ID		ENSG00000159314	ENSG00000147010
Uniprot IDs		E9PIR1 E9PNT2 Q6ZUM4 Q8N2Y9	B7Z6E8 Q5JPT6 Q96B97
PDB IDs		3PP2	2BZ8 2K6D 2K9G 2N64 2O2O 2YDL 5ABS
Enriched GO Terms of Interacting Partners?
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