ELF4 and CASP4

Data Source:
BioGRID (two hybrid)

		ELF4	CASP4
Description		E74 like ETS transcription factor 4	caspase 4
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Nuclear Body PML Body	Extracellular Region Cytoplasm Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Protein-containing Complex IPAF Inflammasome Complex NLRP3 Inflammasome Complex AIM2 Inflammasome Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding Sequence-specific Double-stranded DNA Binding	Cysteine-type Endopeptidase Activity Protein Binding CARD Domain Binding Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway Cysteine-type Endopeptidase Activity Involved In Execution Phase Of Apoptosis
	Biological Process	Natural Killer Cell Proliferation NK T Cell Proliferation Regulation Of Transcription By RNA Polymerase II Cell Differentiation Innate Immune Response Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II	Proteolysis Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Inflammatory Response Protein Autoprocessing Regulation Of Apoptotic Process Innate Immune Response Regulation Of Inflammatory Response Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Pyroptosis Intrinsic Apoptotic Signaling Pathway Execution Phase Of Apoptosis Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Cellular Response To Amyloid-beta
Pathways			NOD1/2 Signaling Pathway
Drugs			Incadronic acid
Diseases
GWAS		Bipolar disorder ( 31043756)	Major depressive disorder ( 29317602)
Interacting Genes		9 interacting genes: CASP4 FBXO4 FBXO7 NPM1 PML RUNX1 SET SKP2 UBB	16 interacting genes: APAF1 APP CASP10 CASP14 CASP3 CASP8 DSP ELF4 IL18 IL1B IL37 MYH9 NOD1 PLA2G4A PSEN1 SERPINB9
Entrez ID		2000	837
HPRD ID		06499	04047
Ensembl ID		ENSG00000102034	ENSG00000196954
Uniprot IDs		Q99607	P49662
PDB IDs			6KMZ 6NRY
Enriched GO Terms of Interacting Partners?
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