EIF4G2 and POLE3

Data Source:
BioGRID (affinity chromatography technology)

		EIF4G2	POLE3
Description		eukaryotic translation initiation factor 4 gamma 2	DNA polymerase epsilon 3, accessory subunit
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Adherens Junction Membrane Eukaryotic Translation Initiation Factor 4F Complex Axon	Nucleus Nucleoplasm Ada2/Gcn5/Ada3 Transcription Activator Complex Epsilon DNA Polymerase Complex CHRAC
	Molecular Function	RNA Binding MRNA Binding Translation Initiation Factor Activity Protein Binding Translation Factor Activity, RNA Binding Cadherin Binding	DNA-directed DNA Polymerase Activity Protein Binding Chromatin DNA Binding Protein Heterodimerization Activity
	Biological Process	Translational Initiation Regulation Of Translational Initiation Cell Cycle Arrest Heart Development Cell Death Negative Regulation Of Autophagy Positive Regulation Of Cell Growth Cellular Macromolecule Biosynthetic Process Positive Regulation Of Translation Positive Regulation Of Axon Extension Positive Regulation Of Dendritic Spine Development	G1/S Transition Of Mitotic Cell Cycle DNA Replication DNA Replication Initiation Leading Strand Elongation Cellular Response To DNA Damage Stimulus Heterochromatin Assembly Telomere Maintenance Via Semi-conservative Replication Nucleosome Mobilization Histone H3 Acetylation DNA Biosynthetic Process
Pathways		ISG15 antiviral mechanism	Recognition of DNA damage by PCNA-containing replication complex PCNA-Dependent Long Patch Base Excision Repair Termination of translesion DNA synthesis HDR through Homologous Recombination (HRR) Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER DNA replication initiation Activation of the pre-replicative complex
Drugs			Cladribine
Diseases
GWAS		Metabolite levels ( 23823483)
Interacting Genes		13 interacting genes: C1QTNF9 CASP3 EIF2S2 EIF3A EIF4A1 EIF4A2 EIF4E EIF5 MKNK1 NCBP1 RPA2 SKIL SUMO2	7 interacting genes: APP BAZ1A CHRAC1 DR1 DRAP1 POLE4 SMARCA5
Entrez ID		1982	54107
HPRD ID		09084	06274
Ensembl ID		ENSG00000110321	ENSG00000148229
Uniprot IDs		P78344 Q2TU89	A0A024R829 Q9NRF9
PDB IDs		3D3M 3L6A 4IUL
Enriched GO Terms of Interacting Partners?
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