EGR2 and NDUFS2

Data Source:
BioGRID (two hybrid)

		EGR2	NDUFS2
Description		early growth response 2	NADH:ubiquinone oxidoreductase core subunit S2
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Intracellular Membrane-bounded Organelle	Nucleoplasm Mitochondrion Mitochondrial Respiratory Chain Complex I Mitochondrial Matrix
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Activating Transcription Factor Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Ubiquitin Protein Ligase Binding Sequence-specific DNA Binding Metal Ion Binding SUMO Ligase Activity HMG Box Domain Binding Sequence-specific Double-stranded DNA Binding	NADH Dehydrogenase Activity Protein Binding NADH Dehydrogenase (ubiquinone) Activity Electron Transfer Activity Ubiquitin Protein Ligase Binding Metal Ion Binding Quinone Binding NAD Binding 4 Iron, 4 Sulfur Cluster Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Protein Export From Nucleus Brain Development Peripheral Nervous System Development Learning Or Memory Rhythmic Behavior Motor Neuron Axon Guidance Gene Expression Schwann Cell Differentiation Positive Regulation Of Schwann Cell Differentiation Protein Sumoylation Facial Nerve Structural Organization Rhombomere 3 Structural Organization Rhombomere 3 Formation Rhombomere 5 Structural Organization Rhombomere 5 Formation Regulation Of Ossification Positive Regulation Of Myelination Response To Insulin Brain Segmentation Skeletal Muscle Cell Differentiation Myelination Fat Cell Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Neuronal Synaptic Plasticity Cellular Response To Organic Substance	Mitochondrial Electron Transport, NADH To Ubiquinone Response To Oxidative Stress Mitochondrial Respiratory Chain Complex I Assembly Mitochondrial ATP Synthesis Coupled Electron Transport
Pathways		Transcriptional regulation of white adipocyte differentiation Activation of anterior HOX genes in hindbrain development during early embryogenesis NGF-stimulated transcription NGF-stimulated transcription EGR2 and SOX10-mediated initiation of Schwann cell myelination EGR2 and SOX10-mediated initiation of Schwann cell myelination	Respiratory electron transport Complex I biogenesis
Drugs			NADH
Diseases		Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy	Mitochondrial respiratory chain deficiencies (MRCD), including: Mitochondrial complex I deficiency (MT-C1D); Complex II deficiency (MT-C2D); Complex III deficiency (MT-C3D); Complex IV deficiency (MT-C4D); Complex V deficiency (MT-ATPSD); Leigh syndrome (LS); Kearns-Sayre Syndrome (KSS); LCHD deficiency (LCHD); Leber Hereditary Optic Neuropathy (LHON); Myoclonic Epilepsy and Ragged-Red Fiber Disease (MERRF); NARP; MELAS; ACAD9 deficiency; HADH deficiency; HIBCH deficiency; GRACILE syndrome
GWAS		Adventurousness ( 30643258) Alopecia areata ( 25608926) Atopic dermatitis ( 23042114) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Ewing sarcoma ( 22327514) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Monocyte percentage of white cells ( 32888494) Selective IgA deficiency ( 27723758) Temperament ( 22832960) Triglyceride levels ( 30698716) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Vogt-Koyanagi-Harada syndrome ( 25108386)	Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 31361310) Asthma ( 31361310 30929738 31619474) Asthma (childhood onset) ( 30929738) Asthma onset (childhood vs adult) ( 30929738) Granulocyte percentage of myeloid white cells ( 27863252)
Interacting Genes		20 interacting genes: ACP5 BPGM DNMT3L GOLGA2 HCFC1 JPT2 MCRS1 MED31 NAB2 NDUFS2 NFATC1 PDE4DIP RBM15B RIMKLB RPL7L1 SOX10 SOX8 SRA1 UBE2I WWP2	5 interacting genes: APP CENPU EGR2 HMOX2 TNFRSF14
Entrez ID		1959	4720
HPRD ID		00551	04285
Ensembl ID		ENSG00000122877	ENSG00000158864
Uniprot IDs		P11161	B7Z792 O75306
PDB IDs			5XTB 5XTC 5XTD 5XTH 5XTI
Enriched GO Terms of Interacting Partners?
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