DUSP6 and TPO

Data Source:
BioGRID (affinity chromatography technology)

		DUSP6	TPO
Description		dual specificity phosphatase 6	thyroid peroxidase
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol	Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane Cell Surface
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Protein Tyrosine/threonine Phosphatase Activity MAP Kinase Tyrosine/serine/threonine Phosphatase Activity Mitogen-activated Protein Kinase Binding Protein Serine Phosphatase Activity Protein Threonine Phosphatase Activity	Iodide Peroxidase Activity Peroxidase Activity Calcium Ion Binding Heme Binding
	Biological Process	MAPK Cascade Activation Of MAPK Activity Inactivation Of MAPK Activity Protein Dephosphorylation Response To Organic Cyclic Compound Cell Differentiation Peptidyl-tyrosine Dephosphorylation Peptidyl-threonine Dephosphorylation Response To Drug Positive Regulation Of Apoptotic Process Response To Nitrosative Stress Regulation Of Heart Growth Negative Regulation Of ERK1 And ERK2 Cascade Response To Growth Factor	Thyroid Hormone Generation Response To Oxidative Stress Embryonic Hemopoiesis Hormone Biosynthetic Process Hydrogen Peroxide Catabolic Process Cellular Oxidant Detoxification
Pathways		RAF-independent MAPK1/3 activation ERKs are inactivated Negative regulation of MAPK pathway Signaling by MAPK mutants	Thyroxine biosynthesis
Drugs			Carbimazole Dextrothyroxine Propylthiouracil Methimazole Triclosan Resorcinol 2-mercaptobenzothiazole
Diseases			Thyroid dyshormonogenesis; Dyshormogenetic goiter
GWAS		Attention deficit hyperactivity disorder ( 29325848 30478444) Night sleep phenotypes ( 27126917)	Autoimmune thyroid disease ( 32581359) Hypothyroidism ( 30367059 27182965) Medication use (thyroid preparations) ( 31015401) Placebo response in major depressive disorder (% change in symptom score) ( 28696415) Thrombin-activatable fibrinolysis inhibitor levels ( 29378355) Thyroid peroxidase antibody levels ( 24586183) Thyroid peroxidase antibody positivity ( 24722205 24586183) Thyroid stimulating hormone levels ( 32769997)
Interacting Genes		12 interacting genes: AATK ERBB4 LMTK2 LTK MAPK1 MAPK3 MDFI ROR2 SRPK1 TEX11 TXK ZNF212	2 interacting genes: DUOX1 TXNDC11
Entrez ID		1848	7173
HPRD ID		04124	06000
Ensembl ID		ENSG00000139318	ENSG00000115705
Uniprot IDs		A0A024RBC1 Q16828 Q53GP9	P07202 Q502Y3 Q6P534
PDB IDs		1HZM 1MKP
Enriched GO Terms of Interacting Partners?
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