DSC1 and DSG2

Data Source:
HPRD (in vivo, in vitro)

		DSC1	DSG2
Description		desmocollin 1	desmoglein 2
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GO Annotations	Cellular Component	Cornified Envelope Plasma Membrane Cell-cell Junction Gap Junction Membrane Integral Component Of Membrane Desmosome Extracellular Exosome Ficolin-1-rich Granule Membrane	Cornified Envelope Plasma Membrane Cell-cell Junction Cell Surface Intercalated Disc Integral Component Of Membrane Apical Plasma Membrane Lateral Plasma Membrane Cell Junction Desmosome Intracellular Membrane-bounded Organelle Extracellular Exosome
	Molecular Function	Calcium Ion Binding Protein Binding	Calcium Ion Binding Cell Adhesion Molecule Binding Cell Adhesive Protein Binding Involved In Bundle Of His Cell-Purkinje Myocyte Communication
	Biological Process	Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Keratinization Neutrophil Degranulation Cornification Cell-cell Adhesion	Desmosome Organization Purkinje Myocyte Development Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Keratinization Response To Progesterone Maternal Process Involved In Female Pregnancy Cornification Bundle Of His Cell-Purkinje Myocyte Adhesion Involved In Cell Communication Regulation Of Heart Rate By Cardiac Conduction Cell-cell Adhesion Regulation Of Ventricular Cardiac Muscle Cell Action Potential
Pathways		Neutrophil degranulation Keratinization Formation of the cornified envelope	Apoptotic cleavage of cell adhesion proteins Keratinization Formation of the cornified envelope
Drugs
Diseases			Arrhythmogenic right ventricular cardiomyopathy (ARVC)
GWAS		Multiple sclerosis ( 23412934)	Blood protein levels ( 30072576 29875488)
Interacting Genes		8 interacting genes: DSG1 DSG2 DSP JUP PKP1 PKP2 PKP3 UCHL5	5 interacting genes: DSC1 DSC2 JUP PKP2 PKP3
Entrez ID		1823	1829
HPRD ID		00511	00516
Ensembl ID		ENSG00000134765	ENSG00000046604
Uniprot IDs		Q08554 Q9HB00	Q14126
PDB IDs		5IRY	2YQG 5ERD 5J5J 6QNT 6QNU 6SIT 7AGF 7AGG
Enriched GO Terms of Interacting Partners?
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