DSC1 and PKP1

Data Source:
HPRD (two hybrid)

		DSC1	PKP1
Description		desmocollin 1	plakophilin 1
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GO Annotations	Cellular Component	Cornified Envelope Plasma Membrane Cell-cell Junction Gap Junction Membrane Integral Component Of Membrane Desmosome Extracellular Exosome Ficolin-1-rich Granule Membrane	Cornified Envelope Nucleus Nucleoplasm Cytoplasm Intermediate Filament Plasma Membrane Adherens Junction Desmosome Ficolin-1-rich Granule Membrane Messenger Ribonucleoprotein Complex
	Molecular Function	Calcium Ion Binding Protein Binding	Protein Binding Lamin Binding Intermediate Filament Binding Structural Constituent Of Skin Epidermis Cadherin Binding
	Biological Process	Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Keratinization Neutrophil Degranulation Cornification Cell-cell Adhesion	Cell-cell Junction Assembly Cell Adhesion Signal Transduction Positive Regulation Of Gene Expression Keratinization Neutrophil Degranulation Intermediate Filament Bundle Assembly Cornification Cell-cell Adhesion Negative Regulation Of MRNA Catabolic Process
Pathways		Neutrophil degranulation Keratinization Formation of the cornified envelope	Apoptotic cleavage of cell adhesion proteins Neutrophil degranulation Keratinization Formation of the cornified envelope
Drugs
Diseases			Ectodermal dysplasia/skin fragility syndrome
GWAS		Multiple sclerosis ( 23412934)	Panic disorder ( 19165232) Youthful appearance (self-reported) ( 32339537)
Interacting Genes		8 interacting genes: DSG1 DSG2 DSP JUP PKP1 PKP2 PKP3 UCHL5	16 interacting genes: BICDL2 CARD10 CEP76 DSC1 DSG1 DSP GOLGA2 GTF2IRD1 HOOK2 HSF2BP KRT14 KRT8 NFKBID TNS2 UCHL5 VIM
Entrez ID		1823	5317
HPRD ID		00511	03579
Ensembl ID		ENSG00000134765	ENSG00000081277
Uniprot IDs		Q08554 Q9HB00	A0A024R952 Q13835
PDB IDs		5IRY	1XM9
Enriched GO Terms of Interacting Partners?
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