DYNC1LI2 and DMTN

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		DYNC1LI2	DMTN
Description		dynein cytoplasmic 1 light intermediate chain 2	dematin actin binding protein
Image
GO Annotations	Cellular Component	Kinetochore Lysosome Late Endosome Centrosome Cytosol Cytoplasmic Dynein Complex Microtubule Membrane	Cytosol Actin Filament Plasma Membrane Endomembrane System Postsynaptic Density Spectrin-associated Cytoskeleton Actin Cytoskeleton Cortical Cytoskeleton Platelet Dense Tubular Network Membrane Cell Projection Membrane Cytoplasmic Vesicle Perinuclear Region Of Cytoplasm
	Molecular Function	Motor Activity ATP Binding Identical Protein Binding Dynein Heavy Chain Binding	Actin Binding Signaling Receptor Binding Protein Binding Spectrin Binding Protein Self-association Actin Filament Binding
	Biological Process	Microtubule Cytoskeleton Organization Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Microtubule-based Movement Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Centrosome Localization Cellular Response To Nerve Growth Factor Stimulus	Cytoskeleton Organization Regulation Of Cell Shape Regulation Of Lamellipodium Assembly Positive Regulation Of Fibroblast Migration Negative Regulation Of Peptidyl-threonine Phosphorylation Negative Regulation Of Cell-substrate Adhesion Lamellipodium Assembly Actin Cytoskeleton Organization Positive Regulation Of Blood Coagulation Regulation Of Actin Cytoskeleton Organization Negative Regulation Of Peptidyl-serine Phosphorylation Calcium-mediated Signaling Using Intracellular Calcium Source Calcium-mediated Signaling Using Extracellular Calcium Source Erythrocyte Development Negative Regulation Of Peptidyl-tyrosine Phosphorylation Actin Filament Bundle Assembly Regulation Of Filopodium Assembly Actin Filament Capping Negative Regulation Of Focal Adhesion Assembly Transmembrane Transport Protein-containing Complex Assembly Protein Secretion By Platelet Cellular Response To Calcium Ion Cellular Response To CAMP Positive Regulation Of Wound Healing Negative Regulation Of Protein Targeting To Membrane Actin Filament Reorganization Negative Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Platelet Aggregation Positive Regulation Of Integrin-mediated Signaling Pathway
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion HSP90 chaperone cycle for steroid hormone receptors (SHR) RHO GTPases Activate Formins COPI-mediated anterograde transport COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase HCMV Early Events Aggrephagy Aggrephagy EML4 and NUDC in mitotic spindle formation	Miscellaneous transport and binding events
Drugs
Diseases
GWAS		Lipid traits ( 30576415)	Apolipoprotein B levels ( 32203549) LDL cholesterol ( 30275531) LDL cholesterol levels ( 32203549) Low density lipoprotein cholesterol levels ( 32154731) Total cholesterol levels ( 30275531)
Interacting Genes		4 interacting genes: APP BRCA2 DMTN GAA	16 interacting genes: ACTB ACTC1 APP CEP76 DYNC1LI2 EPB42 GOLGA2 NEDD4L PRKACA PROCR PTOV1 SNCA SNRPD2 SPTB TEX11 TRAF2
Entrez ID		1783	2039
HPRD ID		09923	00506
Ensembl ID		ENSG00000135720	ENSG00000158856
Uniprot IDs		A0A024R6Z0 O43237 Q63HJ8	Q08495
PDB IDs		6F1T 6F1Y 6F38 6F3A	1QZP 1ZV6
Enriched GO Terms of Interacting Partners?
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