AGER and HMGB1

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro)

		AGER	HMGB1
Description		advanced glycosylation end-product specific receptor	high mobility group box 1
Image
GO Annotations	Cellular Component	Fibrillar Center Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Apical Plasma Membrane Cell Junction Postsynapse	Condensed Chromosome Extracellular Region Extracellular Space Nucleus Nucleoplasm Early Endosome Endoplasmic Reticulum-Golgi Intermediate Compartment Cell Surface Transcription Repressor Complex Secretory Granule Lumen Alphav-beta3 Integrin-HMGB1 Complex Neuron Projection Ficolin-1-rich Granule Lumen
	Molecular Function	Amyloid-beta Binding Transmembrane Signaling Receptor Activity Scavenger Receptor Activity Protein Binding Signaling Receptor Activity Identical Protein Binding S100 Protein Binding Protein-containing Complex Binding Advanced Glycation End-product Receptor Activity	Four-way Junction DNA Binding Bubble DNA Binding Transcription Regulatory Region Sequence-specific DNA Binding Lipopolysaccharide Binding Phosphatidylserine Binding Damaged DNA Binding Double-stranded DNA Binding Single-stranded DNA Binding Transcription Coactivator Activity RNA Binding Double-stranded RNA Binding Single-stranded RNA Binding Cytokine Activity Integrin Binding Protein Binding Transcription Factor Binding DNA Binding, Bending Calcium-dependent Protein Kinase Regulator Activity Lyase Activity C-X-C Chemokine Binding Protein Kinase Activator Activity Chemoattractant Activity RAGE Receptor Binding DNA Polymerase Binding Repressing Transcription Factor Binding Supercoiled DNA Binding
	Biological Process	Response To Hypoxia Microglial Cell Activation Regulation Of T Cell Mediated Cytotoxicity Positive Regulation Of Protein Phosphorylation Endocytosis Inflammatory Response Cell Surface Receptor Signaling Pathway Learning Or Memory Response To Wounding Glucose Mediated Signaling Pathway Neuron Projection Development Negative Regulation Of Interleukin-10 Production Positive Regulation Of Chemokine Production Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Heterotypic Cell-cell Adhesion Positive Regulation Of Activated T Cell Proliferation Positive Regulation Of JUN Kinase Activity Transcytosis Innate Immune Response Positive Regulation Of JNK Cascade Astrocyte Activation Regulation Of Synaptic Plasticity Regulation Of Inflammatory Response Induction Of Positive Chemotaxis Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of DNA Binding Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Monocyte Chemotactic Protein-1 Production Protein Localization To Membrane Modulation Of Age-related Behavioral Decline Regulation Of Spontaneous Synaptic Transmission Transport Across Blood-brain Barrier Regulation Of Long-term Synaptic Potentiation Negative Regulation Of Long-term Synaptic Potentiation Negative Regulation Of Long-term Synaptic Depression Regulation Of P38MAPK Cascade Positive Regulation Of P38MAPK Cascade Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of Aspartic-type Endopeptidase Activity Involved In Amyloid Precursor Protein Catabolic Process Negative Regulation Of Blood Circulation Positive Regulation Of Endothelin Production Negative Regulation Of Connective Tissue Replacement Involved In Inflammatory Response Wound Healing Response To Amyloid-beta Cellular Response To Amyloid-beta Positive Regulation Of Monocyte Extravasation Regulation Of CD4-positive, Alpha-beta T Cell Activation Positive Regulation Of Dendritic Cell Differentiation	Negative Regulation Of Transcription By RNA Polymerase II Eye Development Myeloid Dendritic Cell Activation Endothelial Cell Proliferation Activation Of Innate Immune Response Toll-like Receptor Signaling Pathway Plasmacytoid Dendritic Cell Activation Macrophage Activation Involved In Immune Response Dendritic Cell Chemotaxis Inflammatory Response To Antigenic Stimulus Regulation Of Tolerance Induction Regulation Of T Cell Mediated Immune Response To Tumor Cell DNA Topological Change Base-excision Repair Double-strand Break Repair Via Nonhomologous End Joining Apoptotic DNA Fragmentation DNA Recombination Chromatin Silencing Regulation Of Transcription By RNA Polymerase II Autophagy Inflammatory Response Positive Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Autophagy Viral Process Negative Regulation Of RNA Polymerase II Transcription Preinitiation Complex Assembly Lung Development Neuron Projection Development Chromatin Assembly Regulation Of Restriction Endodeoxyribonuclease Activity Activation Of Protein Kinase Activity DNA Geometric Change Positive Regulation Of Mismatch Repair Tumor Necrosis Factor Production Negative Regulation Of Interferon-gamma Production Positive Regulation Of Interferon-alpha Production Positive Regulation Of Interferon-beta Production Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-1 Production Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production V(D)J Recombination Positive Regulation Of Toll-like Receptor 2 Signaling Pathway Positive Regulation Of Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Toll-like Receptor 9 Signaling Pathway T-helper 1 Cell Activation Endothelial Cell Chemotaxis Positive Regulation Of Activated T Cell Proliferation Positive Regulation Of Apoptotic Process Apoptotic Cell Clearance Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Neutrophil Degranulation Negative Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Positive Regulation Of DNA Binding Positive Regulation Of MAPK Cascade Positive Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Blood Vessel Endothelial Cell Migration T-helper 1 Cell Differentiation Innate Immune Response Positive Regulation Of Myeloid Cell Differentiation Positive Regulation Of Glycogen Catabolic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of JNK Cascade Positive Chemotaxis Positive Regulation Of DNA Ligation Response To Glucocorticoid Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Lipopolysaccharide Positive Regulation Of Monocyte Chemotactic Protein-1 Production Positive Regulation Of Monocyte Chemotaxis Positive Regulation Of Wound Healing Neutrophil Clearance Cellular Response To Interleukin-7 Positive Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of Sprouting Angiogenesis Positive Regulation Of Vascular Endothelial Cell Proliferation Positive Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production Negative Regulation Of Apoptotic Cell Clearance Regulation Of Nucleotide-excision Repair Positive Regulation Of Dendritic Cell Differentiation
Pathways		TAK1 activates NFkB by phosphorylation and activation of IKKs complex Advanced glycosylation endproduct receptor signaling Advanced glycosylation endproduct receptor signaling TRAF6 mediated NF-kB activation	Apoptosis induced DNA fragmentation TAK1 activates NFkB by phosphorylation and activation of IKKs complex Regulation of TLR by endogenous ligand Neutrophil degranulation Advanced glycosylation endproduct receptor signaling Advanced glycosylation endproduct receptor signaling TRAF6 mediated NF-kB activation
Drugs			Chloroquine Ethyl pyruvate
Diseases
GWAS		Advanced glycation end-product levels ( 26083729) Asthma ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 29875488) Blood protein levels in cardiovascular risk ( 28369058) Chronic obstructive pulmonary disease ( 28166215 30804561) Emphysema imaging phenotypes ( 26030696) FEV1 ( 30804560) Inflammatory bowel disease ( 28067908) Lung function (FEV1/FVC) ( 28166213 30804560) Lung function (FVC) ( 30804560) Peak expiratory flow ( 30804560) Percentage gas trapping ( 26030696) Prostate cancer ( 23535732) Pulmonary function ( 20010834 20010835) Pulmonary function (smoking interaction) ( 23284291) Response to Pazopanib in cancer (hepatotoxicity) ( 26546620) Sarcoidosis (non-Lofgren's syndrome without extrapulmonary manifestations) ( 26651848) Ulcerative colitis ( 28067908)	Adult body size ( 32376654) Apolipoprotein A1 levels ( 32203549) Blood osmolality (transformed sodium) ( 28360221) Carotid plaque burden ( 28282560) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Hippocampal volume ( 21116278) Mean corpuscular hemoglobin ( 32888494 27863252) Mean corpuscular volume ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Red blood cell count ( 32888494) Triglyceride levels ( 32203549 32154731) Type 2 diabetes ( 30297969) Urate levels ( 31578528)
Interacting Genes		10 interacting genes: APP C3orf52 CMTM7 CREB3 HMGB1 S100A1 S100A12 S100B S100P TTR	96 interacting genes: ACBD3 AGER AGTRAP AR ATOH1 C1QBP C3 CASP3 CCAR1 CCNDBP1 CDK1 CEBPB CREBBP CRMP1 CSNK1A1 CTCF CTNNBL1 CUX1 DNM2 DNMT1 DUX4 EIF1 ENAH EP300 ERF ERG28 FIP1L1 FOXA3 FOXC1 GTF2A1 HES1 HMGA1 HNRNPK HOXB1 HOXB3 HOXC6 HOXD10 HOXD11 HOXD3 HOXD8 HOXD9 HPF1 HR HSPA5 IRF2 KRT7 LRIF1 MECP2 MNT MT2A NCAN NEUROD6 NEXN NFKB1 NR3C1 PCOLCE PGR PLAT PLG POU5F1 PPP2R3A PRKCA PRKDC PSEN1 PTPRZ1 RAD23B RAG1 RASSF4 RB1 RBPJ RELA RFX1 RPL29 RPS12 RPS20 SIX5 SOX18 SPINT1 TAF1 TBP TERF2 TERF2IP TFE3 TGIF1 TLE1 TLE2 TLE5 TLR2 TLR4 TP53 TP73 UBE2I UNC119 ZFP36 ZNF24 ZNF428
Entrez ID		177	3146
HPRD ID		02568	01228
Ensembl ID		ENSG00000204305	ENSG00000189403
Uniprot IDs		A0A1U9X785 B4DNX3 Q15109	A0A024RDR0 P09429
PDB IDs		1PWI 2BJP 2E5E 2ENS 2L7U 2LE9 2LMB 2M1K 2MJW 2MOV 3CJJ 3O3U 4LP4 4LP5 4OF5 4OFV 4OI7 4OI8 4P2Y 4XYN 4YBH 5D7F	2LY4 2RTU 2YRQ 6CG0 6CIJ 6CIK 6CIL 6CIM 6OEM 6OEN 6OEO
Enriched GO Terms of Interacting Partners?
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