AGER and S100P

Data Source:
HPRD (in vivo)

		AGER	S100P
Description		advanced glycosylation end-product specific receptor	S100 calcium binding protein P
Image
GO Annotations	Cellular Component	Fibrillar Center Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Apical Plasma Membrane Cell Junction Postsynapse	Extracellular Region Nucleus Nucleoplasm Cytoplasm Microvillus Membrane Secretory Granule Lumen Extracellular Exosome
	Molecular Function	Amyloid-beta Binding Transmembrane Signaling Receptor Activity Scavenger Receptor Activity Protein Binding Signaling Receptor Activity Identical Protein Binding S100 Protein Binding Protein-containing Complex Binding Advanced Glycation End-product Receptor Activity	Magnesium Ion Binding Calcium Ion Binding Protein Binding Protein Homodimerization Activity Cadherin Binding Transition Metal Ion Binding Calcium-dependent Protein Binding
	Biological Process	Response To Hypoxia Microglial Cell Activation Regulation Of T Cell Mediated Cytotoxicity Positive Regulation Of Protein Phosphorylation Endocytosis Inflammatory Response Cell Surface Receptor Signaling Pathway Learning Or Memory Response To Wounding Glucose Mediated Signaling Pathway Neuron Projection Development Negative Regulation Of Interleukin-10 Production Positive Regulation Of Chemokine Production Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Heterotypic Cell-cell Adhesion Positive Regulation Of Activated T Cell Proliferation Positive Regulation Of JUN Kinase Activity Transcytosis Innate Immune Response Positive Regulation Of JNK Cascade Astrocyte Activation Regulation Of Synaptic Plasticity Regulation Of Inflammatory Response Induction Of Positive Chemotaxis Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of DNA Binding Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Monocyte Chemotactic Protein-1 Production Protein Localization To Membrane Modulation Of Age-related Behavioral Decline Regulation Of Spontaneous Synaptic Transmission Transport Across Blood-brain Barrier Regulation Of Long-term Synaptic Potentiation Negative Regulation Of Long-term Synaptic Potentiation Negative Regulation Of Long-term Synaptic Depression Regulation Of P38MAPK Cascade Positive Regulation Of P38MAPK Cascade Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of Aspartic-type Endopeptidase Activity Involved In Amyloid Precursor Protein Catabolic Process Negative Regulation Of Blood Circulation Positive Regulation Of Endothelin Production Negative Regulation Of Connective Tissue Replacement Involved In Inflammatory Response Wound Healing Response To Amyloid-beta Cellular Response To Amyloid-beta Positive Regulation Of Monocyte Extravasation Regulation Of CD4-positive, Alpha-beta T Cell Activation Positive Regulation Of Dendritic Cell Differentiation	Response To Organic Substance Neutrophil Degranulation Endothelial Cell Migration
Pathways		TAK1 activates NFkB by phosphorylation and activation of IKKs complex Advanced glycosylation endproduct receptor signaling Advanced glycosylation endproduct receptor signaling TRAF6 mediated NF-kB activation	Neutrophil degranulation
Drugs			Cromoglicic acid
Diseases
GWAS		Advanced glycation end-product levels ( 26083729) Asthma ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 29875488) Blood protein levels in cardiovascular risk ( 28369058) Chronic obstructive pulmonary disease ( 28166215 30804561) Emphysema imaging phenotypes ( 26030696) FEV1 ( 30804560) Inflammatory bowel disease ( 28067908) Lung function (FEV1/FVC) ( 28166213 30804560) Lung function (FVC) ( 30804560) Peak expiratory flow ( 30804560) Percentage gas trapping ( 26030696) Prostate cancer ( 23535732) Pulmonary function ( 20010834 20010835) Pulmonary function (smoking interaction) ( 23284291) Response to Pazopanib in cancer (hepatotoxicity) ( 26546620) Sarcoidosis (non-Lofgren's syndrome without extrapulmonary manifestations) ( 26651848) Ulcerative colitis ( 28067908)	Obesity-related traits ( 23251661)
Interacting Genes		10 interacting genes: APP C3orf52 CMTM7 CREB3 HMGB1 S100A1 S100A12 S100B S100P TTR	15 interacting genes: AGER ARC CACYBP EZR S100A1 S100A2 S100A4 S100B S100Z STUB1 SUGT1 TERF2IP TFIP11 TGFBI UBL4A
Entrez ID		177	6286
HPRD ID		02568	02792
Ensembl ID		ENSG00000204305	ENSG00000163993
Uniprot IDs		A0A1U9X785 B4DNX3 Q15109	P25815
PDB IDs		1PWI 2BJP 2E5E 2ENS 2L7U 2LE9 2LMB 2M1K 2MJW 2MOV 3CJJ 3O3U 4LP4 4LP5 4OF5 4OFV 4OI7 4OI8 4P2Y 4XYN 4YBH 5D7F	1J55 1OZO 2MJW
Enriched GO Terms of Interacting Partners?
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