SPTSSA and BBS2

Data Source:
BioGRID (proximity labelling technology)

		SPTSSA	BBS2
Description		serine palmitoyltransferase small subunit A	Bardet-Biedl syndrome 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane Serine C-palmitoyltransferase Complex	Cytosol Microvillus Membrane Motile Cilium Stereocilium BBSome Ciliary Basal Body Neuron Projection Ciliary Membrane
	Molecular Function	Serine C-palmitoyltransferase Activity Protein Binding	RNA Polymerase II Repressing Transcription Factor Binding Protein Binding
	Biological Process	Protein Localization Sphingolipid Biosynthetic Process Ceramide Biosynthetic Process	Sperm Axoneme Assembly Visual Perception Protein Localization Negative Regulation Of Gene Expression Artery Smooth Muscle Contraction Striatum Development Hippocampus Development Cerebral Cortex Development Adult Behavior Melanosome Transport Protein Localization To Organelle Negative Regulation Of Appetite By Leptin-mediated Signaling Pathway Negative Regulation Of Multicellular Organism Growth Positive Regulation Of Multicellular Organism Growth Vasodilation Golgi To Plasma Membrane Protein Transport Fat Cell Differentiation Photoreceptor Cell Maintenance Brain Morphogenesis Cartilage Development Cilium Assembly Regulation Of Cilium Beat Frequency Involved In Ciliary Motility Non-motile Cilium Assembly
Pathways		Sphingolipid de novo biosynthesis	BBSome-mediated cargo-targeting to cilium
Drugs
Diseases			Bardet-Biedl syndrome (BBS)
GWAS		Intraocular pressure ( 29785010 31959993)
Interacting Genes		8 interacting genes: CYSRT1 GET1 GLP1R HERPUD2 RHBDL1 TMEM31 TUBB3 VKORC1	15 interacting genes: BHMT EEF1A1 EPAS1 EXOC7 FHOD1 FNDC3B HNRNPF HSCB KRT18 LMO4 MDFI NRF1 PAX2 PSME3 RBPMS
Entrez ID		171546	583
HPRD ID		16610	05855
Ensembl ID		ENSG00000165389	ENSG00000125124
Uniprot IDs		Q969W0	Q9BXC9
PDB IDs
Enriched GO Terms of Interacting Partners?
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