RHOV and PAK6

Data Source:
BioGRID (two hybrid)

		RHOV	PAK6
Description		ras homolog family member V	p21 (RAC1) activated kinase 6
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Plasma Membrane Endosome Membrane	Fibrillar Center Nucleoplasm Cytoplasm Cell Junction
	Molecular Function	GTPase Activity Protein Binding GTP Binding Metal Ion Binding	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Cadherin Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	Endocytosis Cell Migration Cell Projection Assembly Cdc42 Protein Signal Transduction Regulation Of Small GTPase Mediated Signal Transduction	Regulation Of Transcription, DNA-templated Protein Phosphorylation Apoptotic Process Cytoskeleton Organization Learning Memory Locomotory Behavior Stress-activated Protein Kinase Signaling Cascade Activation Of Protein Kinase Activity Neuron Projection Arborization Neuron Projection Extension
Pathways		Rho GTPase cycle	Activation of RAC1
Drugs			Fostamatinib
Diseases
GWAS		Malaria ( 31844061) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738)	Obesity-related traits ( 23251661) Schizophrenia ( 25056061 29483656) Weight gain in amisulpride-treated first-episode psychosis ( 32126890)
Interacting Genes		1 interacting genes: PAK6	20 interacting genes: APP AR CDC42 CDK1 DAPK1 ESR1 FBXO7 HSF2BP LIMK1 LRRK1 MAPK14 MDM2 NEK6 PTPRD RAC1 RHOJ RHOV SEMA3B SNX2 TPD52L1
Entrez ID		171177	56924
HPRD ID		10191	06426
Ensembl ID		ENSG00000104140	ENSG00000137843
Uniprot IDs		A0A024R9R2 Q96L33	A0A024R9Q4 Q9NQU5
PDB IDs			2C30 2ODB 4KS7 4KS8 6QDR 6QDS
Enriched GO Terms of Interacting Partners?
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