PAK6 and SEMA3B

Data Source:
BioGRID (two hybrid)

		PAK6	SEMA3B
Description		p21 (RAC1) activated kinase 6	semaphorin 3B
Image			No pdb structure
GO Annotations	Cellular Component	Fibrillar Center Nucleoplasm Cytoplasm Cell Junction	Extracellular Space Endoplasmic Reticulum Integral Component Of Plasma Membrane Collagen-containing Extracellular Matrix
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Cadherin Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity	Semaphorin Receptor Binding Chemorepellent Activity
	Biological Process	Regulation Of Transcription, DNA-templated Protein Phosphorylation Apoptotic Process Cytoskeleton Organization Learning Memory Locomotory Behavior Stress-activated Protein Kinase Signaling Cascade Activation Of Protein Kinase Activity Neuron Projection Arborization Neuron Projection Extension	Neural Crest Cell Migration Cell-cell Signaling Axon Guidance Positive Regulation Of Cell Migration Negative Regulation Of Axon Extension Involved In Axon Guidance Negative Chemotaxis Chemorepulsion Of Axon Semaphorin-plexin Signaling Pathway
Pathways		Activation of RAC1
Drugs		Fostamatinib
Diseases
GWAS		Obesity-related traits ( 23251661) Schizophrenia ( 25056061 29483656) Weight gain in amisulpride-treated first-episode psychosis ( 32126890)	Obese vs. thin ( 30677029) Sleep duration (short sleep) ( 30846698)
Interacting Genes		20 interacting genes: APP AR CDC42 CDK1 DAPK1 ESR1 FBXO7 HSF2BP LIMK1 LRRK1 MAPK14 MDM2 NEK6 PTPRD RAC1 RHOJ RHOV SEMA3B SNX2 TPD52L1	22 interacting genes: BOLL CARD10 CYSRT1 HSF2BP KPRP KRTAP1-1 KRTAP10-8 KRTAP10-9 KRTAP12-2 KRTAP19-5 KRTAP5-9 MDFI NAA10 NBPF19 NOTCH2NLA NRP1 NRP2 PAK6 PICK1 RBPMS2 SEMA3A TRIP13
Entrez ID		56924	7869
HPRD ID		06426	03179
Ensembl ID		ENSG00000137843	ENSG00000012171
Uniprot IDs		A0A024R9Q4 Q9NQU5	A0A0C4DGV8 B4DEK9 Q13214 Q6PI51
PDB IDs		2C30 2ODB 4KS7 4KS8 6QDR 6QDS
Enriched GO Terms of Interacting Partners?
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