DCP2 and CYP27A1

Data Source:
BioGRID (affinity chromatography technology)

		DCP2	CYP27A1
Description		decapping mRNA 2	cytochrome P450 family 27 subfamily A member 1
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GO Annotations	Cellular Component	P-body Nucleoplasm Cytoplasm Cytosol RISC Complex Cell Junction Cytoplasmic Ribonucleoprotein Granule	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix
	Molecular Function	5'-3' Exoribonuclease Activity Protein Binding Exoribonuclease Activity, Producing 5'-phosphomonoesters Manganese Ion Binding M7G(5')pppN Diphosphatase Activity Telomerase RNA Binding	Iron Ion Binding Steroid Hydroxylase Activity Heme Binding Vitamin D3 25-hydroxylase Activity Cholesterol 26-hydroxylase Activity Cholestanetriol 26-monooxygenase Activity
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA MRNA Catabolic Process Negative Regulation Of Telomere Maintenance Via Telomerase Regulation Of MRNA Stability Exonucleolytic Catabolism Of Deadenylated MRNA Histone MRNA Catabolic Process RNA Phosphodiester Bond Hydrolysis, Exonucleolytic Regulation Of Telomerase RNA Localization To Cajal Body	Bile Acid Biosynthetic Process Cholesterol Catabolic Process Cholesterol Metabolic Process Sterol Metabolic Process Calcitriol Biosynthetic Process From Calciol
Pathways		ATF4 activates genes in response to endoplasmic reticulum stress mRNA decay by 5' to 3' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA	Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol Synthesis of bile acids and bile salts via 24-hydroxycholesterol Synthesis of bile acids and bile salts via 27-hydroxycholesterol Endogenous sterols Defective CYP27A1 causes Cerebrotendinous xanthomatosis (CTX)
Drugs
Diseases			Cerebrotendinous xanthomatosis; Van Bogaert-Scherer-Epstein Disease
GWAS		Worry/vulnerability (special factor of neuroticism) ( 30867560)	Diastolic blood pressure ( 30224653) Hemoglobin levels ( 32327693) High light scatter reticulocyte count ( 27863252) Male-pattern baldness ( 28196072) Reticulocyte count ( 27863252)
Interacting Genes		12 interacting genes: AGO1 AGO2 DCP1A DCP1B MIR15B MTOR NAGK POLA2 PSMB1 TRIM21 UPF1 UPF2	2 interacting genes: MTDH PRDX4
Entrez ID		167227	1593
HPRD ID		13125	05939
Ensembl ID		ENSG00000172795	ENSG00000135929
Uniprot IDs		Q8IU60	Q02318
PDB IDs		5MP0 5QOH 5QOI 5QOJ 5QOK 5QOL 5QOM 5QON 5QOO 5QOP 5QOQ 5QOR 5QOS 5QOT 5QOU 5QOV 5QOW 5QOX 5QOY 5QOZ 5QP0 5QP1 5QP2 5QP3 5QP4 5QP5 5QP6 5QP7 5QP8 5QP9 5QPA 5QPB 5QPC	1MFX
Enriched GO Terms of Interacting Partners?
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