DEFB1 and CCR6

Data Source:
HPRD (in vivo)

		DEFB1	CCR6
Description		defensin beta 1	C-C motif chemokine receptor 6
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Golgi Lumen Extrinsic Component Of Membrane Extracellular Exosome Sperm Midpiece Microvesicle	Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Cell Surface Sperm Flagellum Sperm Midpiece Sperm Principal Piece Sperm Plasma Membrane
	Molecular Function	Protein Binding CCR6 Chemokine Receptor Binding Identical Protein Binding	Chemokine Receptor Activity Protein Binding C-C Chemokine Receptor Activity C-C Chemokine Binding Signaling Receptor Activity
	Biological Process	Innate Immune Response In Mucosa Chemotaxis Immune Response G Protein-coupled Receptor Signaling Pathway Response To Bacterium Antimicrobial Humoral Response Antibacterial Humoral Response CAMP-mediated Signaling Calcium-mediated Signaling Using Intracellular Calcium Source Defense Response To Bacterium Innate Immune Response Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Positive Regulation Of Flagellated Sperm Motility Involved In Capacitation Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide	Dendritic Cell Chemotaxis Leukocyte Migration Involved In Inflammatory Response Chemotaxis Immune Response Humoral Immune Response Cellular Defense Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Epithelial Cell Migration Calcium-mediated Signaling Isotype Switching To IgA Isotypes Cell Chemotaxis Positive Regulation Of Flagellated Sperm Motility Involved In Capacitation Chemokine-mediated Signaling Pathway Lymphocyte Migration T Cell Migration Thymocyte Migration DN2 Thymocyte Differentiation DN3 Thymocyte Differentiation Regulation Of T Cell Migration Positive Regulation Of Dendritic Cell Chemotaxis
Pathways		Beta defensins Defensins	Beta defensins Chemokine receptors bind chemokines G alpha (i) signalling events
Drugs
Diseases
GWAS		Blood pressure ( 24954895) Blood protein levels ( 30072576 29875488) Dental caries (decayed and filled deciduous teeth) ( 31533690) Metabolite levels ( 23823483) Night sleep phenotypes ( 27126917) Plasma kynurenine levels in major depressive disorder ( 29317604) Plasma kynurenine to tryptophan ratio in major depressive disorder ( 29317604) Psoriatic arthritis ( 26626624)	Albumin-globulin ratio ( 29403010) Autoimmune thyroid diseases (Graves disease or Hashimoto's thyroiditis) ( 22922229) Basal cell carcinoma ( 31174203) Crohn's disease ( 18587394 28067908 20570966 21102463 23850713) Graves' disease ( 22922229) Inflammatory bowel disease ( 27569725 28067908 23128233) Keratinocyte cancer (MTAG) ( 31174203) Lung cancer ( 28604730) Primary biliary cholangitis ( 28425483) Response to zileuton treatment in asthma (FEV1 change interaction) ( 26031901) Rheumatoid arthritis ( 30423114 24782177 23143596 24390342 20453841 20453842) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676) Social autistic-like traits ( 24133439) Triglycerides ( 24886709) Vitiligo ( 20526339 27723757)
Interacting Genes		6 interacting genes: ASPH CCR6 HAP1 MAP4K2 RIF1 VIM	5 interacting genes: CCL20 DEFB1 DEFB103B DEFB4A QSOX1
Entrez ID		1672	1235
HPRD ID		03634	03498
Ensembl ID		ENSG00000164825	ENSG00000112486
Uniprot IDs		P60022	P51684
PDB IDs		1E4S 1IJU 1IJV 1KJ5 2NLB 2NLC 2NLD 2NLE 2NLF 2NLG 2NLH 2NLP 2NLQ 2NLS 2PLZ	6WWZ
Enriched GO Terms of Interacting Partners?
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