DARS1 and MIRLET7E

Data Source:
BioGRID (unspecified method)

		DARS1	MIRLET7E
Description		aspartyl-tRNA synthetase 1	microRNA let-7e
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Membrane Aminoacyl-tRNA Synthetase Multienzyme Complex Synapse Extracellular Exosome	Extracellular Space
	Molecular Function	RNA Binding Aminoacylase Activity Aspartate-tRNA Ligase Activity Protein Binding ATP Binding	MRNA Binding Involved In Posttranscriptional Gene Silencing
	Biological Process	Translation TRNA Aminoacylation For Protein Translation Aspartyl-tRNA Aminoacylation Protein-containing Complex Assembly	Negative Regulation Of Interleukin-6 Production Gene Silencing By MiRNA MiRNA Mediated Inhibition Of Translation Negative Regulation Of Tyrosine Phosphorylation Of STAT Protein Negative Regulation Of DNA-binding Transcription Factor Activity Negative Regulation Of Interleukin-6-mediated Signaling Pathway Negative Regulation Of Receptor Signaling Pathway Via STAT Negative Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Negative Regulation Of Signaling Receptor Activity
Pathways		Selenoamino acid metabolism Cytosolic tRNA aminoacylation
Drugs		Aspartic acid
Diseases
GWAS
Interacting Genes		78 interacting genes: AIMP2 EEF1A1 ERCC6 ESR1 MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR122 MIR128-1 MIR128-2 MIR138-1 MIR138-2 MIR140 MIR141 MIR143 MIR145 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR17 MIR18A MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR206 MIR20A MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29A MIR29B1 MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR9-3 MIR92A1 MIR92A2 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I PIK3R3 SUMO2	105 interacting genes: AIMP1 AIMP2 APOBEC3B AQR ATXN2L C1QBP CDC40 CDC5L CELF1 CHERP CPSF1 CRTAP DARS1 DDX1 DDX21 DDX23 DDX3X DHX36 DHX37 EDC4 EIF2AK2 EPRS1 ERAL1 FAM98A FAM98B FUS G3BP2 GRSF1 HNRNPA0 HNRNPA1 HNRNPA2B1 HNRNPA3 HNRNPF HNRNPH1 HNRNPH2 HNRNPH3 HNRNPK HNRNPL HNRNPM HNRNPR IARS1 IGF2BP1 IGF2BP2 IGF2BP3 KARS1 KNOP1 LARP7 LARS1 LIN28A LIN28B LRPPRC MARS1 MATR3 MSI2 MYEF2 NOL6 NONO NUDT16L1 NUDT21 NUFIP2 PDCD11 PGAM5 PLOD1 PLRG1 PRMT1 PTBP1 PUF60 PUM1 PUM2 PURA QARS1 RARS1 RBFOX2 RBM10 RBM14 RBM4 RBM47 RBM5 RTCB SART3 SF3A1 SF3A3 SF3B1 SF3B2 SF3B3 SF3B4 SFPQ SPOUT1 STRBP SUGP2 SYMPK SYNCRIP TAF15 TRA2A TRA2B TUT7 U2SURP UPF1 UTP20 XAB2 YBX1 YBX2 YBX3 ZFR ZNF346
Entrez ID		1615	406887
HPRD ID		04361
Ensembl ID		ENSG00000115866	ENSG00000198972
Uniprot IDs		A0A140VJW5 P14868
PDB IDs		4J15 5Y6L 6IY6
Enriched GO Terms of Interacting Partners?
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