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DARS1 and MIR21
Data Source:
BioGRID
(unspecified method)
DARS1
MIR21
Description
aspartyl-tRNA synthetase 1
microRNA 21
Image
No pdb structure
GO Annotations
Cellular Component
Cytoplasm
Cytosol
Membrane
Aminoacyl-tRNA Synthetase Multienzyme Complex
Synapse
Extracellular Exosome
Extracellular Space
Cytoplasm
Extracellular Exosome
Extracellular Vesicle
Molecular Function
RNA Binding
Aminoacylase Activity
Aspartate-tRNA Ligase Activity
Protein Binding
ATP Binding
MRNA 3'-UTR Binding
MRNA Binding Involved In Posttranscriptional Gene Silencing
Biological Process
Translation
TRNA Aminoacylation For Protein Translation
Aspartyl-tRNA Aminoacylation
Protein-containing Complex Assembly
Blood Vessel Development
Positive Regulation Of Cytokine Production
Positive Regulation Of Protein Phosphorylation
Negative Regulation Of Endothelial Cell Proliferation
Negative Regulation Of Cytokine-mediated Signaling Pathway
Transforming Growth Factor Beta Receptor Signaling Pathway
Embryo Implantation
Positive Regulation Of Cell Population Proliferation
Negative Regulation Of Cell Population Proliferation
Regulation Of Cell Shape
Positive Regulation Of Endothelial Cell Migration
Negative Regulation Of Endothelial Cell Migration
Positive Regulation Of Cardiac Muscle Hypertrophy
Negative Regulation Of Cardiac Muscle Hypertrophy
Positive Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Negative Regulation Of Cardiac Muscle Cell Apoptotic Process
Positive Regulation Of Epithelial To Mesenchymal Transition
Positive Regulation Of Keratinocyte Proliferation
Positive Regulation Of Phosphatidylinositol 3-kinase Signaling
Negative Regulation Of Angiogenesis
Regulation Of Cell Migration
Positive Regulation Of Cell Migration
Negative Regulation Of Cell Migration
BMP Signaling Pathway
Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Positive Regulation Of Cell Projection Organization
Negative Regulation Of NF-kappaB Transcription Factor Activity
Activation Of Protein Kinase B Activity
Negative Regulation Of Type I Interferon Production
Negative Regulation Of Interleukin-12 Production
Negative Regulation Of Interleukin-21 Production
Collagen Metabolic Process
Negative Regulation Of GTPase Activity
Negative Regulation Of Smooth Muscle Cell Apoptotic Process
Gene Silencing By MiRNA
MiRNA Mediated Inhibition Of Translation
Phenotypic Switching
Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Positive Regulation Of Activated T Cell Proliferation
Positive Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Negative Regulation Of MAPK Cascade
Negative Regulation Of Regulatory T Cell Differentiation
Positive Regulation Of Fat Cell Differentiation
Positive Regulation Of Endothelial Cell Differentiation
Positive Regulation Of Osteoblast Differentiation
Positive Regulation Of Angiogenesis
Negative Regulation Of Innate Immune Response
Positive Regulation Of Inflammatory Response
Negative Regulation Of Stress Fiber Assembly
Regulation Of Protein Kinase B Signaling
Positive Regulation Of Protein Kinase B Signaling
Negative Regulation Of Type I Interferon-mediated Signaling Pathway
Epithelial To Mesenchymal Transition Involved In Cardiac Fibroblast Development
Negative Regulation Of Cartilage Development
Endothelial Tube Morphogenesis
Negative Regulation Of ERK1 And ERK2 Cascade
Positive Regulation Of ERK1 And ERK2 Cascade
Cellular Response To Lipopolysaccharide
Cellular Response To Virus
Positive Regulation Of Inflammatory Response To Wounding
Positive Regulation Of Cytokine Production Involved In Inflammatory Response
Positive Regulation Of Cellular Response To Hypoxia
Negative Regulation Of Arginine Catabolic Process
Positive Regulation Of Vascular Endothelial Growth Factor Signaling Pathway
Negative Regulation Of NIK/NF-kappaB Signaling
Negative Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death
Negative Regulation Of Superoxide Dismutase Activity
Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator
Regulation Of Signal Transduction Involved In Mitotic G2 DNA Damage Checkpoint
Regulation Of Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel
Negative Regulation Of Chondrocyte Proliferation
Negative Regulation Of Reactive Oxygen Species Biosynthetic Process
Positive Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis
Positive Regulation Of Potassium Ion Export Across Plasma Membrane
Cellular Response To Resveratrol
Positive Regulation Of Metalloendopeptidase Activity
Positive Regulation Of Vascular Associated Smooth Muscle Contraction
Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation
Positive Regulation Of Replicative Senescence
Negative Regulation Of Vascular Associated Smooth Muscle Cell Migration
Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration
Positive Regulation Of Myofibroblast Differentiation
Negative Regulation Of Hydrogen Sulfide Biosynthetic Process
Negative Regulation Of Aortic Smooth Muscle Cell Differentiation
Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell
Positive Regulation Of Vascular Associated Smooth Muscle Cell Differentiation
Negative Regulation Of Vascular Associated Smooth Muscle Cell Apoptotic Process
Positive Regulation Of Vascular Endothelial Cell Proliferation
Negative Regulation Of Endothelial Tube Morphogenesis
Retinal Cell Apoptotic Process
Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Positive Regulation Of T-helper 17 Type Immune Response
Positive Regulation Of T-helper 17 Cell Differentiation
Regulation Of Reactive Oxygen Species Metabolic Process
Negative Regulation Of Interleukin-1-mediated Signaling Pathway
Pathways
Selenoamino acid metabolism
Cytosolic tRNA aminoacylation
Drugs
Aspartic acid
Diseases
GWAS
Monocyte count (
29403010
)
Interacting Genes
78 interacting genes:
AIMP2
EEF1A1
ERCC6
ESR1
MIR1-1
MIR1-2
MIR106A
MIR106B
MIR107
MIR10B
MIR122
MIR128-1
MIR128-2
MIR138-1
MIR138-2
MIR140
MIR141
MIR143
MIR145
MIR155
MIR15A
MIR15B
MIR16-1
MIR16-2
MIR17
MIR18A
MIR18B
MIR199A1
MIR199A2
MIR19A
MIR19B1
MIR19B2
MIR200A
MIR200B
MIR200C
MIR205
MIR206
MIR20A
MIR20B
MIR21
MIR214
MIR221
MIR222
MIR25
MIR29A
MIR29B1
MIR29B2
MIR29C
MIR31
MIR34A
MIR34B
MIR34C
MIR363
MIR429
MIR451A
MIR7-1
MIR7-2
MIR7-3
MIR9-1
MIR9-2
MIR9-3
MIR92A1
MIR92A2
MIR93
MIR98
MIRLET7A1
MIRLET7A2
MIRLET7A3
MIRLET7B
MIRLET7C
MIRLET7D
MIRLET7E
MIRLET7F1
MIRLET7F2
MIRLET7G
MIRLET7I
PIK3R3
SUMO2
95 interacting genes:
AIMP2
APOBEC3B
ATXN2L
C1QBP
CELF1
CELF2
CPSF1
CSTF3
DARS1
DDX1
DDX21
DDX3X
DHX36
DHX37
EDC4
EIF2AK2
EPRS1
ERAL1
ESRP1
FAM98A
FUS
G3BP2
HNRNPA0
HNRNPA1
HNRNPA2B1
HNRNPA3
HNRNPF
HNRNPH1
HNRNPH2
HNRNPH3
HNRNPK
HNRNPL
HNRNPM
HNRNPR
IARS1
IGF2BP1
IGF2BP2
IGF2BP3
KARS1
KNOP1
LARP7
LARS1
LIN28A
LRPPRC
MARS1
MATR3
MSI2
MYEF2
NOL6
NONO
NUDT16L1
NUFIP2
PATL1
PDCD11
PGAM5
PTBP1
PTBP3
PTCD3
PUF60
PUM1
PURA
QARS1
RARS1
RBFOX2
RBM10
RBM14
RBM17
RBM4
RBM4B
RTCA
RTCB
SF3B1
SF3B2
SF3B3
SF3B4
SF3B5
SFPQ
SPOUT1
SUGP2
SYMPK
SYNCRIP
TAF15
TENT2
TRA2A
TRA2B
TRIM25
U2SURP
UPF1
USP36
UTP20
YBX1
YBX2
YBX3
ZFR
ZNF106
Entrez ID
1615
406991
HPRD ID
04361
Ensembl ID
ENSG00000115866
ENSG00000284190
Uniprot IDs
A0A140VJW5
P14868
PDB IDs
4J15
5Y6L
6IY6
Enriched GO Terms of Interacting Partners
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