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DAG1 and TLN1
Data Source:
BioGRID
(fluorescent resonance energy transfer)
DAG1
TLN1
Description
dystroglycan 1
talin 1
Image
GO Annotations
Cellular Component
Extracellular Region
Basement Membrane
Extracellular Space
Nucleoplasm
Cytoplasm
Endoplasmic Reticulum Lumen
Golgi Lumen
Cytosol
Cytoskeleton
Plasma Membrane
Adherens Junction
Focal Adhesion
External Side Of Plasma Membrane
Dystrophin-associated Glycoprotein Complex
Dystroglycan Complex
Integral Component Of Membrane
Lamellipodium
Filopodium
Node Of Ranvier
Nuclear Periphery
Sarcolemma
Costamere
Intracellular Membrane-bounded Organelle
Plasma Membrane Raft
Postsynaptic Membrane
Collagen-containing Extracellular Matrix
Extracellular Exosome
Contractile Ring
Glutamatergic Synapse
GABA-ergic Synapse
Postsynaptic Cytosol
Ruffle
Extracellular Region
Cytosol
Cytoskeleton
Plasma Membrane
Adherens Junction
Focal Adhesion
Cell Surface
Ruffle Membrane
Extracellular Exosome
Molecular Function
Virus Receptor Activity
Dystroglycan Binding
Actin Binding
Calcium Ion Binding
Protein Binding
Structural Constituent Of Muscle
Tubulin Binding
Vinculin Binding
SH2 Domain Binding
Laminin Binding
Laminin-1 Binding
Alpha-actinin Binding
Phosphatidylserine Binding
Integrin Binding
Structural Constituent Of Cytoskeleton
Protein Binding
Vinculin Binding
LIM Domain Binding
Phosphatidylinositol Binding
Cadherin Binding
Actin Filament Binding
Biological Process
Positive Regulation Of Cell-matrix Adhesion
Morphogenesis Of An Epithelium
Morphogenesis Of An Epithelial Sheet
Membrane Protein Ectodomain Proteolysis
Axon Guidance
Aging
Regulation Of Gastrulation
Regulation Of Epithelial To Mesenchymal Transition
Response To Denervation Involved In Regulation Of Muscle Adaptation
Muscle Attachment
Calcium-dependent Cell-matrix Adhesion
Regulation Of Embryonic Cell Shape
Modulation By Virus Of Host Process
Nerve Development
Nerve Maturation
Myelination In Peripheral Nervous System
Extracellular Matrix Organization
Negative Regulation Of Cell Migration
Axon Regeneration
Positive Regulation Of Myelination
Microtubule Anchoring
Skeletal Muscle Tissue Regeneration
Negative Regulation Of MAPK Cascade
Response To Peptide Hormone
Positive Regulation Of Protein Kinase Activity
Viral Entry Into Host Cell
Positive Regulation Of Oligodendrocyte Differentiation
Regulation Of Synapse Organization
Negative Regulation Of Protein Kinase B Signaling
Angiogenesis Involved In Wound Healing
Epithelial Tube Branching Involved In Lung Morphogenesis
Branching Involved In Salivary Gland Morphogenesis
Cellular Response To Mechanical Stimulus
Cellular Response To Cholesterol
Commissural Neuron Axon Guidance
Basement Membrane Organization
Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane
Retrograde Trans-synaptic Signaling By Trans-synaptic Protein Complex
Positive Regulation Of Basement Membrane Assembly Involved In Embryonic Body Morphogenesis
Platelet Degranulation
Muscle Contraction
Cell-cell Junction Assembly
Cell-substrate Junction Assembly
Integrin-mediated Signaling Pathway
Viral Process
Cortical Actin Cytoskeleton Organization
Integrin Activation
IRE1-mediated Unfolded Protein Response
Platelet Aggregation
Cell-cell Adhesion
Pathways
Non-integrin membrane-ECM interactions
ECM proteoglycans
ECM proteoglycans
Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3
Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2
Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1
O-linked glycosylation
Regulation of expression of SLITs and ROBOs
EGR2 and SOX10-mediated initiation of Schwann cell myelination
Platelet degranulation
Integrin signaling
GRB2:SOS provides linkage to MAPK signaling for Integrins
p130Cas linkage to MAPK signaling for integrins
XBP1(S) activates chaperone genes
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
Smooth Muscle Contraction
MAP2K and MAPK activation
Signaling by moderate kinase activity BRAF mutants
Signaling by high-kinase activity BRAF mutants
Signaling by BRAF and RAF fusions
Paradoxical activation of RAF signaling by kinase inactive BRAF
Signaling downstream of RAS mutants
Signaling by RAF1 mutants
Drugs
Diseases
Limb-girdle muscular dystrophy (LGMD)
GWAS
Blood protein levels (
29875488
28240269
)
Body mass index (
26426971
)
Brain morphology (min-P) (
32665545
)
Brain morphology (MOSTest) (
32665545
)
Cortical surface area (MOSTest) (
32665545
)
Crohn's disease (
28067908
)
Estimated glomerular filtration rate (
31152163
)
Extremely high intelligence (
29520040
)
Gut microbiota (functional units) (
27694959
)
Inflammatory bowel disease (
28067908
)
Intelligence (MTAG) (
29326435
)
Mood instability (
31168069
)
Pediatric autoimmune diseases (
26301688
)
Plateletcrit (
32888494
)
Refractive error (
32231278
)
Regular attendance at a religious group (
29970889
)
Resting heart rate (
27798624
)
Sleep duration (short sleep) (
30846698
)
Subcortical volume (min-P) (
32665545
)
Subcortical volume (MOSTest) (
32665545
)
Ulcerative colitis (
28067908
)
Brain morphology (MOSTest) (
32665545
)
IgE levels in asthmatics (
23967269
)
Lymphocyte counts (
32888494
)
Monocyte count (
32888494
)
Platelet distribution width (
32888494
27863252
)
Plateletcrit (
32888494
)
Interacting Genes
25 interacting genes:
AGR2
AGR3
AGRN
BGN
CAV1
CAV3
DMD
DRP2
FYN
GRB2
ITGB1
LAMA1
LAMA2
LAMA5
MAGI1
MAP2
NCK1
RAPSN
SHC1
SRC
TLN1
TUBA1A
UTRN
WWP1
WWP2
29 interacting genes:
ABI1
ACTA1
AZIN2
CDK5
DAG1
DOK1
EGFR
ERBB2
ITGA1
ITGA2B
ITGB1
ITGB2
ITGB3
ITGB5
ITGB7
LRP2
MTNR1A
MTNR1B
NRAP
PKD1
PTK2
PTK2B
PXN
SMURF1
SUMO2
TES
TUBA1A
VCL
YWHAQ
Entrez ID
1605
7094
HPRD ID
00546
01726
Ensembl ID
ENSG00000173402
ENSG00000137076
Uniprot IDs
A0A024R2W4
Q14118
Q9Y490
PDB IDs
1EG4
2MK7
5GGP
5LLK
6JJY
1SYQ
2MWN
4DJ9
6R9T
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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