TLN1 and AZIN2

Data Source:
BioGRID (unspecified method)

		TLN1	AZIN2
Description		talin 1	antizyme inhibitor 2
Image			No pdb structure
GO Annotations	Cellular Component	Ruffle Extracellular Region Cytosol Cytoskeleton Plasma Membrane Adherens Junction Focal Adhesion Cell Surface Ruffle Membrane Extracellular Exosome	Nucleus Cytoplasm Mitochondrion Cis-Golgi Network Trans-Golgi Network Cytosol Transport Vesicle Axon Dendrite Cytoplasmic Vesicle Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Perikaryon Perinuclear Region Of Cytoplasm Granular Vesicle
	Molecular Function	Phosphatidylserine Binding Integrin Binding Structural Constituent Of Cytoskeleton Protein Binding Vinculin Binding LIM Domain Binding Phosphatidylinositol Binding Cadherin Binding Actin Filament Binding	Ornithine Decarboxylase Activity Protein Binding Arginine Decarboxylase Activity Ornithine Decarboxylase Activator Activity
	Biological Process	Platelet Degranulation Muscle Contraction Cell-cell Junction Assembly Cell-substrate Junction Assembly Integrin-mediated Signaling Pathway Viral Process Cortical Actin Cytoskeleton Organization Integrin Activation IRE1-mediated Unfolded Protein Response Platelet Aggregation Cell-cell Adhesion	Spermatogenesis Putrescine Biosynthetic Process From Ornithine Negative Regulation Of Protein Catabolic Process Positive Regulation Of Catalytic Activity Agmatine Biosynthetic Process Trans-Golgi Network Membrane Organization Positive Regulation Of Polyamine Transmembrane Transport
Pathways		Platelet degranulation Integrin signaling GRB2:SOS provides linkage to MAPK signaling for Integrins p130Cas linkage to MAPK signaling for integrins XBP1(S) activates chaperone genes SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion Smooth Muscle Contraction MAP2K and MAPK activation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants Signaling by RAF1 mutants	Agmatine biosynthesis
Drugs			Pyridoxal phosphate Arginine
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) IgE levels in asthmatics ( 23967269) Lymphocyte counts ( 32888494) Monocyte count ( 32888494) Platelet distribution width ( 32888494 27863252) Plateletcrit ( 32888494)	Pursuit maintenance gain ( 29064472)
Interacting Genes		29 interacting genes: ABI1 ACTA1 AZIN2 CDK5 DAG1 DOK1 EGFR ERBB2 ITGA1 ITGA2B ITGB1 ITGB2 ITGB3 ITGB5 ITGB7 LRP2 MTNR1A MTNR1B NRAP PKD1 PTK2 PTK2B PXN SMURF1 SUMO2 TES TUBA1A VCL YWHAQ	3 interacting genes: OAZ3 PSMC5 TLN1
Entrez ID		7094	113451
HPRD ID		01726	17657
Ensembl ID		ENSG00000137076	ENSG00000142920
Uniprot IDs		Q9Y490	B3KV62 D3DPR0 Q96A70
PDB IDs		1SYQ 2MWN 4DJ9 6R9T
Enriched GO Terms of Interacting Partners?
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