TLN1 and NRAP

Data Source:
HPRD (in vitro)

		TLN1	NRAP
Description		talin 1	nebulin related anchoring protein
Image			No pdb structure
GO Annotations	Cellular Component	Ruffle Extracellular Region Cytosol Cytoskeleton Plasma Membrane Adherens Junction Focal Adhesion Cell Surface Ruffle Membrane Extracellular Exosome	Fascia Adherens Muscle Tendon Junction Z Disc
	Molecular Function	Phosphatidylserine Binding Integrin Binding Structural Constituent Of Cytoskeleton Protein Binding Vinculin Binding LIM Domain Binding Phosphatidylinositol Binding Cadherin Binding Actin Filament Binding	Actin Binding Protein Binding Metal Ion Binding Actin Filament Binding Muscle Alpha-actinin Binding
	Biological Process	Platelet Degranulation Muscle Contraction Cell-cell Junction Assembly Cell-substrate Junction Assembly Integrin-mediated Signaling Pathway Viral Process Cortical Actin Cytoskeleton Organization Integrin Activation IRE1-mediated Unfolded Protein Response Platelet Aggregation Cell-cell Adhesion	Biological_process Muscle Fiber Development Cardiac Muscle Thin Filament Assembly
Pathways		Platelet degranulation Integrin signaling GRB2:SOS provides linkage to MAPK signaling for Integrins p130Cas linkage to MAPK signaling for integrins XBP1(S) activates chaperone genes SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion Smooth Muscle Contraction MAP2K and MAPK activation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants Signaling by RAF1 mutants
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) IgE levels in asthmatics ( 23967269) Lymphocyte counts ( 32888494) Monocyte count ( 32888494) Platelet distribution width ( 32888494 27863252) Plateletcrit ( 32888494)	Heel bone mineral density ( 30598549) Plasma factor VII activating protease levels ( 30070759) QT interval ( 29874175)
Interacting Genes		29 interacting genes: ABI1 ACTA1 AZIN2 CDK5 DAG1 DOK1 EGFR ERBB2 ITGA1 ITGA2B ITGB1 ITGB2 ITGB3 ITGB5 ITGB7 LRP2 MTNR1A MTNR1B NRAP PKD1 PTK2 PTK2B PXN SMURF1 SUMO2 TES TUBA1A VCL YWHAQ	8 interacting genes: ACTA1 ACTB ACTN3 KLHL41 PRKAA2 TLN1 TRIM63 VCL
Entrez ID		7094	4892
HPRD ID		01726	04189
Ensembl ID		ENSG00000137076	ENSG00000197893
Uniprot IDs		Q9Y490	A0A0A0MRM2 Q86VF7
PDB IDs		1SYQ 2MWN 4DJ9 6R9T
Enriched GO Terms of Interacting Partners?
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