USP51 and USP28

Data Source:
BioGRID (enzymatic study)

		USP51	USP28
Description		ubiquitin specific peptidase 51	ubiquitin specific peptidase 28
Image		No pdb structure
GO Annotations	Cellular Component	Chromosome	Nucleus Nucleoplasm Cytosol Nuclear Body Protein-containing Complex
	Molecular Function	Chromatin Binding Thiol-dependent Ubiquitin-specific Protease Activity Cysteine-type Peptidase Activity Zinc Ion Binding Histone Binding	Cysteine-type Endopeptidase Activity Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding
	Biological Process	DNA Repair Ubiquitin-dependent Protein Catabolic Process Regulation Of Cell Cycle Process Regulation Of Double-strand Break Repair Via Homologous Recombination Histone Deubiquitination Protein Deubiquitination Protein Phosphopantetheinylation Regulation Of Response To DNA Damage Stimulus Regulation Of Double-strand Break Repair Via Nonhomologous End Joining	DNA Damage Checkpoint DNA Repair Ubiquitin-dependent Protein Catabolic Process Cellular Response To DNA Damage Stimulus Ras Protein Signal Transduction Cell Population Proliferation Response To Ionizing Radiation Protein Deubiquitination Protein Phosphopantetheinylation Regulation Of Protein Stability Cellular Response To UV Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator
Pathways			Ub-specific processing proteases
Drugs
Diseases
GWAS		Educational attainment (years of education) ( 30038396) Mean corpuscular volume ( 29403010) Smoking initiation ( 24665060)	Alcohol consumption (drinks per week) ( 30643258) Low density lipoprotein cholesterol levels ( 32154731) PR interval ( 32439900)
Interacting Genes		8 interacting genes: H2AC20 H2AC4 H2BC3 PJA1 USP15 USP21 USP28 ZEB1	40 interacting genes: ATXN3L BAP1 CLSPN ESPL1 HIF1A JOSD1 KDM1A MAP3K1 MDC1 MTNR1A NSMCE2 OTUB1 OTUB2 PJA1 PLA2G2A PRKD1 RFFL SENP1 SENP8 STAM STAMBP SUMO2 TP53 TP53BP1 TRIM55 TRIM63 UBC UCHL1 UCHL3 UCHL5 USP14 USP15 USP20 USP21 USP33 USP4 USP5 USP51 USP7 USP8
Entrez ID		158880	57646
HPRD ID		07167	15632
Ensembl ID		ENSG00000247746	ENSG00000048028
Uniprot IDs		Q70EK9	B4E3L3 Q96RU2
PDB IDs			2LVA 2MUU 6H4H 6H4I 6HEH 6HEI 6HEJ 6HEK
Enriched GO Terms of Interacting Partners?
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