USP51 and ZEB1

Data Source:
BioGRID (pull down)

		USP51	ZEB1
Description		ubiquitin specific peptidase 51	zinc finger E-box binding homeobox 1
Image		No pdb structure
GO Annotations	Cellular Component	Chromosome	Chromatin Nucleus Nucleoplasm Cytosol
	Molecular Function	Chromatin Binding Thiol-dependent Ubiquitin-specific Protease Activity Cysteine-type Peptidase Activity Zinc Ion Binding Histone Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding E-box Binding
	Biological Process	DNA Repair Ubiquitin-dependent Protein Catabolic Process Regulation Of Cell Cycle Process Regulation Of Double-strand Break Repair Via Homologous Recombination Histone Deubiquitination Protein Deubiquitination Protein Phosphopantetheinylation Regulation Of Response To DNA Damage Stimulus Regulation Of Double-strand Break Repair Via Nonhomologous End Joining	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Nervous System Development Cytokine-mediated Signaling Pathway Cell Differentiation Negative Regulation Of Endothelial Cell Differentiation Positive Regulation Of Neuron Differentiation Negative Regulation Of Transcription, DNA-templated Anatomical Structure Development
Pathways			Interleukin-4 and Interleukin-13 signaling
Drugs
Diseases			Posterior polymorphous corneal dystrophy (PPCD) Fuchs corneal dystrophy (FECD); Fuchs endothelial corneal dystrophy
GWAS		Educational attainment (years of education) ( 30038396) Mean corpuscular volume ( 29403010) Smoking initiation ( 24665060)	Pulse pressure ( 28135244) Uterine fibroids ( 31649266) Waist-hip ratio ( 20935629) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		8 interacting genes: H2AC20 H2AC4 H2BC3 PJA1 USP15 USP21 USP28 ZEB1	11 interacting genes: ATM CDK6 CTBP1 CTBP2 DRAP1 EP300 KAT5 SMAD2 SMAD3 SMAD7 USP51
Entrez ID		158880	6935
HPRD ID		07167	01798
Ensembl ID		ENSG00000247746	ENSG00000148516
Uniprot IDs		Q70EK9	B2RBI8 B4DGU2 P37275
PDB IDs			2E19
Enriched GO Terms of Interacting Partners?
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