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USP28

Description ubiquitin specific peptidase 28
Image
GO Annotations Cellular Component
  • Nucleus
  • Nucleoplasm
  • Cytosol
  • Nuclear Body
  • Protein-containing Complex
Molecular Function
  • Cysteine-type Endopeptidase Activity
  • Thiol-dependent Ubiquitin-specific Protease Activity
  • Protein Binding
Biological Process
  • DNA Damage Checkpoint
  • DNA Repair
  • Ubiquitin-dependent Protein Catabolic Process
  • Cellular Response To DNA Damage Stimulus
  • Ras Protein Signal Transduction
  • Cell Population Proliferation
  • Response To Ionizing Radiation
  • Protein Deubiquitination
  • Protein Phosphopantetheinylation
  • Regulation Of Protein Stability
  • Cellular Response To UV
  • Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator
Pathways
  • Ub-specific processing proteases
Drugs
Diseases
GWAS
  • Alcohol consumption (drinks per week) ( 30643258)
  • Low density lipoprotein cholesterol levels ( 32154731)
  • PR interval ( 32439900)
Interacting Genes 40 interacting genes: ATXN3L BAP1 CLSPN ESPL1 HIF1A JOSD1 KDM1A MAP3K1 MDC1 MTNR1A NSMCE2 OTUB1 OTUB2 PJA1 PLA2G2A PRKD1 RFFL SENP1 SENP8 STAM STAMBP SUMO2 TP53 TP53BP1 TRIM55 TRIM63 UBC UCHL1 UCHL3 UCHL5 USP14 USP15 USP20 USP21 USP33 USP4 USP5 USP51 USP7 USP8
Entrez ID 57646
HPRD ID 15632
Ensembl ID ENSG00000048028
Uniprot IDs B4E3L3 Q96RU2
PDB IDs 2LVA 2MUU 6H4H 6H4I 6HEH 6HEI 6HEJ 6HEK
Enriched GO Terms of Interacting Partners?
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© Madhavi K. Ganapathiraju 2012-2025