CYP11A1 and FDX1

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		CYP11A1	FDX1
Description		cytochrome P450 family 11 subfamily A member 1	ferredoxin 1
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GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix	Mitochondrion Mitochondrial Matrix
	Molecular Function	Iron Ion Binding Protein Binding Cholesterol Monooxygenase (side-chain-cleaving) Activity Heme Binding	Iron Ion Binding Electron Transfer Activity 2 Iron, 2 Sulfur Cluster Binding
	Biological Process	C21-steroid Hormone Biosynthetic Process Glucocorticoid Biosynthetic Process Cholesterol Metabolic Process Sterol Metabolic Process Cortisol Metabolic Process Vitamin D Metabolic Process Cellular Response To Peptide Hormone Stimulus	C21-steroid Hormone Biosynthetic Process Cholesterol Metabolic Process Sterol Metabolic Process Electron Transport Chain Hormone Biosynthetic Process Small Molecule Metabolic Process Cellular Response To CAMP Cellular Response To Forskolin
Pathways		Pregnenolone biosynthesis Endogenous sterols Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR)	Mitochondrial iron-sulfur cluster biogenesis Pregnenolone biosynthesis Endogenous sterols Electron transport from NADPH to Ferredoxin Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR)
Drugs		Aminoglutethimide	Mitotane
Diseases		46,XY disorders of sex development (Disorders in androgen synthesis or action), including: Congenital adrenal hyperplasias; Leydig cell hypoplasia; Androgen insensitivity syndrome (AIS) Congenital adrenal hyperplasia (CAH)
GWAS		Coffee consumption (cups per day) ( 31837886) Craniofacial microsomia ( 26853712) Diisocyanate-induced asthma ( 25918132)	Cognitive function ( 24684796) Coronary artery disease ( 32469254)
Interacting Genes		5 interacting genes: CYP11B2 FDX1 SMAD2 SMAD3 SMAD9	5 interacting genes: CYCS CYP11A1 CYP11B2 FDXR PRKAB2
Entrez ID		1583	2230
HPRD ID		00326	00059
Ensembl ID		ENSG00000140459	ENSG00000137714
Uniprot IDs		A0A0S2Z3R3 P05108	P10109
PDB IDs		3N9Y 3N9Z 3NA0 3NA1	3N9Y 3N9Z 3NA0 3NA1 3P1M
Enriched GO Terms of Interacting Partners?
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