CYP11B1 and CYP11B2

Data Source:
HPRD (in vitro)

		CYP11B1	CYP11B2
Description		cytochrome P450 family 11 subfamily B member 1	cytochrome P450 family 11 subfamily B member 2
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GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane	Mitochondrion Mitochondrial Inner Membrane
	Molecular Function	Steroid 11-beta-monooxygenase Activity Iron Ion Binding Heme Binding Corticosterone 18-monooxygenase Activity	Steroid 11-beta-monooxygenase Activity Iron Ion Binding Steroid Hydroxylase Activity Heme Binding Corticosterone 18-monooxygenase Activity
	Biological Process	C21-steroid Hormone Biosynthetic Process Glucocorticoid Biosynthetic Process Immune Response Cholesterol Metabolic Process Regulation Of Blood Pressure Sterol Metabolic Process Aldosterone Biosynthetic Process Cellular Response To Hormone Stimulus Cortisol Metabolic Process Cortisol Biosynthetic Process Cellular Response To Potassium Ion Glucose Homeostasis Cellular Response To Peptide Hormone Stimulus	Regulation Of Blood Volume By Renal Aldosterone Renal Water Homeostasis C21-steroid Hormone Biosynthetic Process Glucocorticoid Biosynthetic Process Mineralocorticoid Biosynthetic Process Cholesterol Metabolic Process Sterol Metabolic Process Aldosterone Biosynthetic Process Cellular Response To Hormone Stimulus Cortisol Metabolic Process Cortisol Biosynthetic Process Cellular Response To Potassium Ion Potassium Ion Homeostasis Sodium Ion Homeostasis Cellular Response To Peptide Hormone Stimulus
Pathways		Glucocorticoid biosynthesis Endogenous sterols Defective CYP11B1 causes Adrenal hyperplasia 4 (AH4)	Mineralocorticoid biosynthesis Glucocorticoid biosynthesis Endogenous sterols Defective CYP11B2 causes Corticosterone methyloxidase 1 deficiency (CMO-1 deficiency)
Drugs		Mitotane Metyrapone Levoketoconazole Osilodrostat	Spironolactone Osilodrostat
Diseases		Glucocorticoid-remediable aldosteronism (GRA) Congenital adrenal hyperplasia (CAH) 46,XX disorders of sex development (Disorders related to androgen excess), including: Congenital adrenal hyperplasias; Glucocorticoid resistance; Aromatase deficiency	Glucocorticoid-remediable aldosteronism (GRA) Aldosterone synthase deficiency; Corticosterone methyloxidase type I deficiency; Corticosterone methyloxidase type II deficiency
GWAS		Hypertension ( 30487518) Mean arterial pressure ( 30487518) Pulse pressure ( 30487518) Systolic blood pressure ( 29403010)	Diastolic blood pressure ( 27841878 30487518) Hypertension ( 30487518) Mean arterial pressure ( 29403010 30487518) Medication use (diuretics) ( 31015401) Plasma androstenedione levels in resected early stage-receptor positive breast cancer ( 28429243) Pulse pressure ( 30487518) Systolic blood pressure ( 27841878 29403010 30487518 30578418)
Interacting Genes		1 interacting genes: CYP11B2	3 interacting genes: CYP11A1 CYP11B1 FDX1
Entrez ID		1584	1585
HPRD ID		01943	00492
Ensembl ID		ENSG00000160882	ENSG00000179142
Uniprot IDs		P15538 Q8TDD0	P19099
PDB IDs		6M7X	4DVQ 4FDH 4ZGX 6XZ8 6XZ9
Enriched GO Terms of Interacting Partners?
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