CYP4A11 and CYB5A

Data Source:
BioGRID (enzymatic study)

		CYP4A11	CYB5A
Description		cytochrome P450 family 4 subfamily A member 11	cytochrome b5 type A
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Membrane Apical Plasma Membrane Intracellular Membrane-bounded Organelle	Mitochondrial Outer Membrane Endoplasmic Reticulum Membrane Cytosol Membrane Integral Component Of Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Iron Ion Binding Arachidonic Acid Monooxygenase Activity Arachidonic Acid Epoxygenase Activity Alkane 1-monooxygenase Activity Heme Binding Leukotriene-B4 20-monooxygenase Activity Aromatase Activity Long-chain Fatty Acid Omega-hydroxylase Activity	Cytochrome-c Oxidase Activity Protein Binding Electron Transfer Activity Enzyme Binding Heme Binding Metal Ion Binding
	Biological Process	Long-chain Fatty Acid Metabolic Process Kidney Development Renal Water Homeostasis Pressure Natriuresis Fatty Acid Metabolic Process Leukotriene Metabolic Process Regulation Of Lipid Metabolic Process Arachidonic Acid Metabolic Process Epoxygenase P450 Pathway Oxylipin Biosynthetic Process Positive Regulation Of Icosanoid Secretion Leukotriene B4 Catabolic Process Linoleic Acid Metabolic Process Icosanoid Biosynthetic Process Lauric Acid Metabolic Process Sodium Ion Homeostasis Omega-hydroxylase P450 Pathway	L-ascorbic Acid Metabolic Process Electron Transport Chain Response To Cadmium Ion Proton Transmembrane Transport
Pathways		PPARA activates gene expression Fatty acids Miscellaneous substrates Eicosanoids Synthesis of Leukotrienes (LT) and Eoxins (EX) Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)	Vitamin C (ascorbate) metabolism
Drugs		NADH	Dimethyl Propionate Ester Heme Chromium Chromic citrate Chromic nitrate Chromium gluconate Chromium nicotinate Chromous sulfate
Diseases			Methemoglobinemia
GWAS		Blood metabolite levels ( 24816252) Blood metabolite ratios ( 24816252) Serum metabolite levels ( 23093944) Urinary metabolite levels in chronic kidney disease ( 31959995)	Blood protein levels ( 30072576)
Interacting Genes		2 interacting genes: CYB5A PIK3R1	14 interacting genes: CYB5R3 CYCS CYP17A1 CYP1A1 CYP1A2 CYP2A6 CYP2D6 CYP2E1 CYP2W1 CYP3A4 CYP4A11 POR SCD UGT1A4
Entrez ID		1579	1528
HPRD ID		03201	08941
Ensembl ID		ENSG00000187048	ENSG00000166347
Uniprot IDs		Q02928	A0A384ME44 P00167
PDB IDs			2I96
Enriched GO Terms of Interacting Partners?
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