CYB5A and CYP2A6

Data Source:
BioGRID (pull down)

		CYB5A	CYP2A6
Description		cytochrome b5 type A	cytochrome P450 family 2 subfamily A member 6
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GO Annotations	Cellular Component	Mitochondrial Outer Membrane Endoplasmic Reticulum Membrane Cytosol Membrane Integral Component Of Membrane Intracellular Membrane-bounded Organelle	Cytoplasm Endoplasmic Reticulum Membrane Cytoplasmic Microtubule Intracellular Membrane-bounded Organelle
	Molecular Function	Cytochrome-c Oxidase Activity Protein Binding Electron Transfer Activity Enzyme Binding Heme Binding Metal Ion Binding	Iron Ion Binding Coumarin 7-hydroxylase Activity Arachidonic Acid Epoxygenase Activity Steroid Hydroxylase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen Enzyme Binding Heme Binding
	Biological Process	L-ascorbic Acid Metabolic Process Electron Transport Chain Response To Cadmium Ion Proton Transmembrane Transport	Organic Acid Metabolic Process Xenobiotic Metabolic Process Steroid Metabolic Process Coumarin Metabolic Process Drug Metabolic Process Epoxygenase P450 Pathway Exogenous Drug Catabolic Process Coumarin Catabolic Process
Pathways		Vitamin C (ascorbate) metabolism	Xenobiotics CYP2E1 reactions
Drugs		Dimethyl Propionate Ester Heme Chromium Chromic citrate Chromic nitrate Chromium gluconate Chromium nicotinate Chromous sulfate	Coumarin N,N-DIMETHYL(5-(PYRIDIN-3-YL)FURAN-2-YL)METHANAMINE N-METHYL(5-(PYRIDIN-3-YL)FURAN-2-YL)METHANAMINE (5-(PYRIDIN-3-YL)FURAN-2-YL)METHANAMINE 4,4'-DIPYRIDYL DISULFIDE
Diseases		Methemoglobinemia
GWAS		Blood protein levels ( 30072576)	Alanine transaminase levels ( 29403010) Aspartate aminotransferase levels ( 29403010) Bitter beverage consumption ( 31046077) Bitter non-alcoholic beverage consumption ( 31046077) Blood protein levels ( 28240269) Caffeine metabolism (plasma 1,7-dimethylxanthine (paraxanthine) level) ( 27702941) Caffeine metabolism (plasma 1,7-dimethylxanthine (paraxanthine) to 1,3,7-trimethylxanthine (caffeine) ratio) ( 27702941) Caffeine metabolism (plasma 3,7-dimethylxanthine (theobromine) level) ( 27702941) Carotid intima media thickness (mean) ( 31801372) Cerebrospinal fluid p-Tau181p:AB1-42 ratio ( 26252872) Cerebrospinal P-tau181p levels ( 26252872) Chronic obstructive pulmonary disease ( 22080838 28166215) Chronotype ( 30696823) Coffee consumption ( 31046077) Local histogram emphysema pattern ( 25006744) Low density lipoprotein cholesterol levels ( 32154731) Lung adenocarcinoma ( 28604730) Lung cancer ( 28604730) Lung cancer in ever smokers ( 28604730) Nicotine metabolite ratio in current smokers ( 27488534 28921760 26407342) Non-small cell lung cancer ( 31326317) Parental longevity (father's attained age) ( 29227965) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245) Smoking behavior ( 23049750 20418888 20418890) Smoking behaviour (cigarette pack-years) ( 30679032) Smoking behaviour (cigarettes smoked per day) ( 31089300 30617275 30679032) Squamous cell lung carcinoma ( 28604730) Urinary sodium excretion ( 31409800)
Interacting Genes		14 interacting genes: CYB5R3 CYCS CYP17A1 CYP1A1 CYP1A2 CYP2A6 CYP2D6 CYP2E1 CYP2W1 CYP3A4 CYP4A11 POR SCD UGT1A4	2 interacting genes: CYB5A POR
Entrez ID		1528	1548
HPRD ID		08941	00420
Ensembl ID		ENSG00000166347	ENSG00000255974
Uniprot IDs		A0A384ME44 P00167	P11509
PDB IDs		2I96	1Z10 1Z11 2FDU 2FDV 2FDW 2FDY 3EBS 3T3Q 3T3R 4EJJ 4RUI
Enriched GO Terms of Interacting Partners?
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