CYB5A and UGT1A4

Data Source:
BioGRID (two hybrid)

		CYB5A	UGT1A4
Description		cytochrome b5 type A	UDP glucuronosyltransferase family 1 member A4
Image			No pdb structure
GO Annotations	Cellular Component	Mitochondrial Outer Membrane Endoplasmic Reticulum Membrane Cytosol Membrane Integral Component Of Membrane Intracellular Membrane-bounded Organelle	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane
	Molecular Function	Cytochrome-c Oxidase Activity Protein Binding Electron Transfer Activity Enzyme Binding Heme Binding Metal Ion Binding	Retinoic Acid Binding Glucuronosyltransferase Activity Enzyme Binding Protein Homodimerization Activity
	Biological Process	L-ascorbic Acid Metabolic Process Electron Transport Chain Response To Cadmium Ion Proton Transmembrane Transport	Bilirubin Conjugation Heme Catabolic Process Cellular Glucuronidation Flavonoid Glucuronidation Xenobiotic Glucuronidation Vitamin D3 Metabolic Process
Pathways		Vitamin C (ascorbate) metabolism	Glucuronidation Heme degradation Defective UGT1A4 causes hyperbilirubinemia
Drugs		Dimethyl Propionate Ester Heme Chromium Chromic citrate Chromic nitrate Chromium gluconate Chromium nicotinate Chromous sulfate
Diseases		Methemoglobinemia
GWAS		Blood protein levels ( 30072576)	Bilirubin levels ( 32084209) Hair greying ( 26926045) Liver disease biomarker ( 30576415) Low density lipoprotein cholesterol levels ( 32154731) Plasma norclozapine levels in treatment-resistant schizophrenia ( 30922102) Serum metabolite levels ( 23093944) Total bilirubin levels ( 29403010) Total bilirubin levels in HIV-1 infection ( 25884002)
Interacting Genes		14 interacting genes: CYB5R3 CYCS CYP17A1 CYP1A1 CYP1A2 CYP2A6 CYP2D6 CYP2E1 CYP2W1 CYP3A4 CYP4A11 POR SCD UGT1A4	1 interacting genes: CYB5A
Entrez ID		1528	54657
HPRD ID		08941	08402
Ensembl ID		ENSG00000166347	ENSG00000244474
Uniprot IDs		A0A384ME44 P00167	P22310
PDB IDs		2I96
Enriched GO Terms of Interacting Partners?
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