PRAG1 and PSAP

Data Source:
BioGRID (two hybrid)

		PRAG1	PSAP
Description		PEAK1 related, kinase-activating pseudokinase 1	prosaposin
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GO Annotations	Cellular Component	Nucleus Cytoplasm Focal Adhesion	Extracellular Region Extracellular Space Lysosome Lysosomal Membrane Late Endosome Plasma Membrane Azurophil Granule Membrane Lysosomal Lumen Intracellular Membrane-bounded Organelle Collagen-containing Extracellular Matrix Extracellular Exosome
	Molecular Function	Protein Kinase Activity Protein Binding ATP Binding Identical Protein Binding	Protease Binding Beta-galactosidase Activity Protein Binding Phospholipid Binding Enzyme Activator Activity Lipid Binding Protein Homodimerization Activity Ganglioside GM1 Binding Ganglioside GM2 Binding Ganglioside GM3 Binding Ganglioside GT1b Binding Ganglioside GP1c Binding
	Biological Process	Protein Phosphorylation Regulation Of Cell Shape Regulation Of Notch Signaling Pathway Negative Regulation Of Neuron Projection Development Cell Migration Positive Regulation Of Rho Protein Signal Transduction Regulation Of Cell Motility	Platelet Degranulation Glycosphingolipid Metabolic Process Lipid Transport Lysosomal Transport G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Regulation Of Autophagy Regulation Of Lipid Metabolic Process Neutrophil Degranulation Regulation Of Catalytic Activity Prostate Gland Growth Epithelial Cell Differentiation Involved In Prostate Gland Development Ganglioside GM1 Transport To Membrane
Pathways			Platelet degranulation Glycosphingolipid metabolism Peptide ligand-binding receptors G alpha (i) signalling events Neutrophil degranulation
Drugs			Di-Stearoyl-3-Sn-Phosphatidylethanolamine
Diseases			Krabbe disease; Globoid cell leukodystrophy Metachromatic leukodystrophy (MLD) Gaucher disease
GWAS		Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Estimated glomerular filtration rate ( 31152163) Fish- and plant-related diet ( 32066663) Processed meat consumption ( 32066663) Remission after SSRI treatment in MDD or neuroticism ( 29559929) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Thyroid stimulating hormone levels ( 32769997) TPE interval (resting) ( 32386560)	Asthma (childhood onset) ( 23829686) Seasonality and depression ( 30217971)
Interacting Genes		3 interacting genes: CHGB PSAP UBE3A	20 interacting genes: APPBP2 BACE1 BRCA1 CD1B CELSR1 COPS6 CPEB2 CTSD ERBB2 GBA MAFF NLGN3 PEX5 PRAG1 SGCG SMAD2 SMAD9 UBE3A USP4 ZBED1
Entrez ID		157285	5660
HPRD ID		19497	01460
Ensembl ID		ENSG00000275342	ENSG00000197746
Uniprot IDs		Q86YV5	A0A024QZQ2 P07602
PDB IDs		5VE6	1M12 1N69 1SN6 2DOB 2GTG 2QYP 2R0R 2R1Q 2RB3 2Z9A 3BQP 3BQQ 4DDJ 4UEX 4V2O 6SLR
Enriched GO Terms of Interacting Partners?
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