PSAP and GBA

Data Source:
HPRD (in vitro)

		PSAP	GBA
Description		prosaposin	glucosylceramidase beta
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Lysosome Lysosomal Membrane Late Endosome Plasma Membrane Azurophil Granule Membrane Lysosomal Lumen Intracellular Membrane-bounded Organelle Collagen-containing Extracellular Matrix Extracellular Exosome	Lysosome Lysosomal Membrane Endoplasmic Reticulum Golgi Apparatus Trans-Golgi Network Extrinsic Component Of Membrane Lysosomal Lumen Extracellular Exosome
	Molecular Function	Protease Binding Beta-galactosidase Activity Protein Binding Phospholipid Binding Enzyme Activator Activity Lipid Binding Protein Homodimerization Activity Ganglioside GM1 Binding Ganglioside GM2 Binding Ganglioside GM3 Binding Ganglioside GT1b Binding Ganglioside GP1c Binding	Glucosylceramidase Activity Signaling Receptor Binding Scavenger Receptor Binding Protein Binding Glucosyltransferase Activity Steryl-beta-glucosidase Activity
	Biological Process	Platelet Degranulation Glycosphingolipid Metabolic Process Lipid Transport Lysosomal Transport G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Regulation Of Autophagy Regulation Of Lipid Metabolic Process Neutrophil Degranulation Regulation Of Catalytic Activity Prostate Gland Growth Epithelial Cell Differentiation Involved In Prostate Gland Development Ganglioside GM1 Transport To Membrane	Glucosylceramide Catabolic Process Glycosphingolipid Metabolic Process Autophagy Mitochondrion Organization Lysosome Organization Cholesterol Metabolic Process Determination Of Adult Lifespan Cellular Response To Starvation Response To PH Microglia Differentiation Regulation Of Macroautophagy Antigen Processing And Presentation Lipid Storage Cerebellar Purkinje Cell Layer Formation Pyramidal Neuron Differentiation Termination Of Signal Transduction Lipid Glycosylation Neuron Projection Development Negative Regulation Of Protein-containing Complex Assembly Regulation Of TOR Signaling Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Interleukin-6 Production T Cell Differentiation In Thymus Regulation Of Water Loss Via Skin Response To Testosterone Positive Regulation Of Protein Dephosphorylation Cell Death In Response To Oxidative Stress Positive Regulation Of Protein-containing Complex Disassembly Negative Regulation Of MAP Kinase Activity Negative Regulation Of Neuron Apoptotic Process Skin Morphogenesis Response To Estrogen Sphingosine Biosynthetic Process Ceramide Biosynthetic Process Cell Maturation Brain Morphogenesis Homeostasis Of Number Of Cells Negative Regulation Of Inflammatory Response Neuromuscular Process Positive Regulation Of Protein Metabolic Process Neuron Apoptotic Process Microglial Cell Proliferation Motor Behavior Cellular Response To Tumor Necrosis Factor Hematopoietic Stem Cell Proliferation Response To Dexamethasone Lymphocyte Migration Response To Thyroid Hormone Negative Regulation Of Neuron Death Beta-glucoside Catabolic Process Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Protein Lipidation Positive Regulation Of Neuronal Action Potential Positive Regulation Of Autophagy Of Mitochondrion In Response To Mitochondrial Depolarization Autophagosome Organization Regulation Of Lysosomal Protein Catabolic Process
Pathways		Platelet degranulation Glycosphingolipid metabolism Peptide ligand-binding receptors G alpha (i) signalling events Neutrophil degranulation	Glycosphingolipid metabolism Association of TriC/CCT with target proteins during biosynthesis
Drugs		Di-Stearoyl-3-Sn-Phosphatidylethanolamine	scyllo-inositol N-acetyl-alpha-D-glucosamine Velaglucerase alfa (2R,3R,4R,5S)-2-(HYDROXYMETHYL)-1-NONYLPIPERIDINE-3,4,5-TRIOL
Diseases		Krabbe disease; Globoid cell leukodystrophy Metachromatic leukodystrophy (MLD) Gaucher disease	Lewy body dementia (LBD); Dementia with Lewy bodies (DLB) Gaucher disease Progressive myoclonic epilepsy (PME), including: Lafora disease (LBD); Unverricht-Lundborg disease (ULD); Neuronal ceroid lipofuscinoses (NCL); Type I sialidosis; Action myoclonus-renal failure syndrome (AMRF); Type III Gaucher disease (GD)
GWAS		Asthma (childhood onset) ( 23829686) Seasonality and depression ( 30217971)	Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Crohn's disease ( 28067908) Dementia with Lewy bodies ( 29263008 31065058) Inflammatory bowel disease ( 28067908) Intracranial aneurysm ( 30823506) Parkinson's disease ( 22451204 25064009 27182965 24842889 28892059 21738487) Renal function-related traits (BUN) ( 22797727) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		20 interacting genes: APPBP2 BACE1 BRCA1 CD1B CELSR1 COPS6 CPEB2 CTSD ERBB2 GBA MAFF NLGN3 PEX5 PRAG1 SGCG SMAD2 SMAD9 UBE3A USP4 ZBED1	3 interacting genes: NEDD4 PSAP SNCA
Entrez ID		5660	2629
HPRD ID		01460	06973
Ensembl ID		ENSG00000197746	ENSG00000177628
Uniprot IDs		A0A024QZQ2 P07602	A0A068F658 B7Z6S9 P04062
PDB IDs		1M12 1N69 1SN6 2DOB 2GTG 2QYP 2R0R 2R1Q 2RB3 2Z9A 3BQP 3BQQ 4DDJ 4UEX 4V2O 6SLR	1OGS 1Y7V 2F61 2J25 2NSX 2NT0 2NT1 2V3D 2V3E 2V3F 2VT0 2WCG 2WKL 2XWD 2XWE 3GXD 3GXF 3GXI 3GXM 3KE0 3KEH 3RIK 3RIL 5LVX 6MOZ 6Q1N 6Q1P 6Q6K 6Q6L 6Q6N 6TJJ 6TJK 6TJQ 6TN1
Enriched GO Terms of Interacting Partners?
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