CYC1 and CYCS

Data Source:
BioGRID (enzymatic study)
HPRD (in vitro)

		CYC1	CYCS
Description		cytochrome c1	cytochrome c, somatic
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GO Annotations	Cellular Component	Nucleus Mitochondrion Mitochondrial Inner Membrane Mitochondrial Respiratory Chain Complex III Membrane Integral Component Of Membrane	Protein Phosphatase Type 2A Complex Nucleus Mitochondrion Mitochondrial Inner Membrane Mitochondrial Intermembrane Space Cytosol Respirasome
	Molecular Function	Protein Binding Heme Binding Metal Ion Binding	Protein Serine/threonine Phosphatase Activity Protein Binding Heme Binding Metal Ion Binding
	Biological Process	Mitochondrial Electron Transport, Ubiquinol To Cytochrome C Response To Glucagon	Mitochondrial Electron Transport, Ubiquinol To Cytochrome C Mitochondrial Electron Transport, Cytochrome C To Oxygen Protein Dephosphorylation Apoptotic Process Mitochondrion Organization Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C Cellular Response To Oxidative Stress Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cellular Respiration
Pathways		Mitochondrial protein import Respiratory electron transport	Release of apoptotic factors from the mitochondria Formation of apoptosome Activation of caspases through apoptosome-mediated cleavage SMAC (DIABLO) binds to IAPs SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes Transcriptional activation of mitochondrial biogenesis Detoxification of Reactive Oxygen Species TP53 Regulates Metabolic Genes Respiratory electron transport Regulation of the apoptosome activity Regulation of the apoptosome activity
Drugs		2-Hexyloxy-6-Hydroxymethyl-Tetrahydro-Pyran-3,4,5-Triol 6-Hydroxy-5-undecyl-4,7-benzothiazoledione Azoxystrobin 5-Heptyl-6-hydroxy-1,3-benzothiazole-4,7-dione (5S)-3-ANILINO-5-(2,4-DIFLUOROPHENYL)-5-METHYL-1,3-OXAZOLIDINE-2,4-DIONE (S)-famoxadone METHYL (2Z)-3-METHOXY-2-{2-[(E)-2-PHENYLVINYL]PHENYL}ACRYLATE 2-Nonyl-4-quinolinol 1-oxide Ubiquinone Q2	Minocycline Protoporphyrin Ix Containing Co Ferroheme C Imidazole Zinc protoporphyrin Trimethyllysine Zinc Substituted Heme C Artenimol
Diseases			Thrombocytopenia (THC); Familial platelet disorder with associated myeloid malignancy (FPDMM)
GWAS		Asthma ( 31959851) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494)	Alzheimer's disease (cognitive decline) ( 23535033) High density lipoprotein cholesterol levels ( 30498476) Systemic lupus erythematosus ( 19838195)
Interacting Genes		2 interacting genes: CYCS UQCRFS1	22 interacting genes: AGTPBP1 APAF1 BCL2 BCL2L1 CASP9 COX4I2 CUL9 CYB5A CYB5R1 CYB5R3 CYC1 FDX1 HSPA8 HSPB1 KRT40 MEOX2 NDOR1 RNF7 SAFB SNCA UQCRC1 VDAC2
Entrez ID		1537	54205
HPRD ID		00480	00479
Ensembl ID		ENSG00000179091	ENSG00000172115
Uniprot IDs		P08574	G4XXL9 P99999
PDB IDs		5XTE 5XTH 5XTI	1J3S 2N3Y 2N9I 2N9J 3NWV 3ZCF 3ZOO 5EXQ 5O10 5TY3 6DUJ 6ECJ
Enriched GO Terms of Interacting Partners?
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