CTSC and XRN2

Data Source:
BioGRID (two hybrid)

		CTSC	XRN2
Description		cathepsin C	5'-3' exoribonuclease 2
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Extracellular Region Extracellular Space Nucleoplasm Lysosome Endoplasmic Reticulum Lumen Centrosome Membrane COPII-coated ER To Golgi Transport Vesicle Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Azurophil Granule Lumen Intracellular Membrane-bounded Organelle Collagen-containing Extracellular Matrix Extracellular Exosome	Nucleus Nucleoplasm Nucleolus Membrane Aggresome
	Molecular Function	Cysteine-type Endopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Cysteine-type Peptidase Activity Dipeptidyl-peptidase Activity Peptidase Activator Activity Involved In Apoptotic Process Phosphatase Binding Chloride Ion Binding Identical Protein Binding Protein Self-association Chaperone Binding	3'-5'-exoribonuclease Activity Transcription Termination Site Sequence-specific DNA Binding RNA Binding Nuclease Activity 5'-3' Exoribonuclease Activity Protein Binding 5'-3' Exonuclease Activity Identical Protein Binding Metal Ion Binding
	Biological Process	T Cell Mediated Cytotoxicity Proteolysis Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Apoptotic Process Immune Response Aging Response To Organic Substance Negative Regulation Of Myelination Neutrophil Degranulation COPII Vesicle Coating Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Microglial Cell Activation Positive Regulation Of Apoptotic Signaling Pathway	DNA Catabolic Process, Exonucleolytic Nuclear-transcribed MRNA Catabolic Process DNA-templated Transcription, Termination RRNA Processing RNA Processing MRNA Processing RNA Catabolic Process Spermatogenesis RNA Metabolic Process Hippocampus Development Neuron Differentiation Retina Development In Camera-type Eye RNA Phosphodiester Bond Hydrolysis, Exonucleolytic
Pathways		COPII-mediated vesicle transport MHC class II antigen presentation Cargo concentration in the ER Neutrophil degranulation	Association of TriC/CCT with target proteins during biosynthesis Major pathway of rRNA processing in the nucleolus and cytosol
Drugs
Diseases		Papillon-Lefevre syndrome Haim-Munk syndrome
GWAS		Basophil percentage of white cells ( 32888494) Blood protein levels ( 30072576) Neurological blood protein biomarker levels ( 31320639)	Autism spectrum disorder ( 30804558) Lupus nephritis in systemic lupus erythematosus ( 24925725) Mean corpuscular hemoglobin ( 32888494 27863252) Mean corpuscular volume ( 32888494) Red cell distribution width ( 32888494)
Interacting Genes		3 interacting genes: CAPN1 CTSL XRN2	28 interacting genes: ALDH1B1 ATRN COMT CRY2 CSNK2A1 CTSC DXO DYNLT1 EEF1A1 EIF3L EIF5A EIF6 ERG EXOSC10 EXOSC8 LCN2 LSM3 MOCS3 MRPL4 MRPS10 PLEKHF2 PRAME PSMA3 TARDBP TIPARP TOLLIP TTC23 UPF2
Entrez ID		1075	22803
HPRD ID		03841	10309
Ensembl ID		ENSG00000109861	ENSG00000088930
Uniprot IDs		P53634	B4DZC3 Q9H0D6
PDB IDs		1K3B 2DJF 2DJG 3PDF 4CDC 4CDD 4CDE 4CDF 4OEL 4OEM
Enriched GO Terms of Interacting Partners?
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