HSPA8 and SUMO4

Data Source:
HPRD (in vivo)

		HSPA8	SUMO4
Description		heat shock protein family A (Hsp70) member 8	small ubiquitin like modifier 4
Image			No pdb structure
GO Annotations	Cellular Component	Prp19 Complex Extracellular Region Extracellular Space Nucleus Nucleoplasm Spliceosomal Complex Nucleolus Cytoplasm Lysosome Lysosomal Membrane Late Endosome Autophagosome Cytosol Plasma Membrane Focal Adhesion Membrane Dendrite Secretory Granule Lumen Melanosome Terminal Bouton Lysosomal Lumen Perinuclear Region Of Cytoplasm Clathrin-sculpted Gamma-aminobutyric Acid Transport Vesicle Membrane Extracellular Exosome Blood Microparticle Lumenal Side Of Lysosomal Membrane Photoreceptor Ribbon Synapse Glycinergic Synapse Glutamatergic Synapse Presynaptic Cytosol Postsynaptic Cytosol Postsynaptic Specialization Membrane Chaperone Complex Ficolin-1-rich Granule Lumen Ribonucleoprotein Complex	Nucleus SUMO Ligase Complex
	Molecular Function	G Protein-coupled Receptor Binding Phosphatidylserine Binding RNA Binding Protein Binding ATP Binding ATPase Activity Enzyme Binding MHC Class II Protein Complex Binding Protein-macromolecule Adaptor Activity Heat Shock Protein Binding Ubiquitin Protein Ligase Binding Protein Folding Chaperone Cadherin Binding Unfolded Protein Binding Chaperone Binding Misfolded Protein Binding C3HC4-type RING Finger Domain Binding Clathrin-uncoating ATPase Activity	Molecular_function Protein Tag Ubiquitin-like Protein Ligase Binding
	Biological Process	MRNA Splicing, Via Spliceosome Protein Folding Response To Unfolded Protein Neurotransmitter Secretion Cellular Response To Starvation Viral Process Vesicle-mediated Transport Cytokine-mediated Signaling Pathway Regulation Of Protein Stability Cellular Response To Unfolded Protein Protein Refolding Regulation Of Protein-containing Complex Assembly Neutrophil Degranulation Regulation Of MRNA Stability Positive Regulation By Host Of Viral Genome Replication Negative Regulation Of Transcription, DNA-templated ATP Metabolic Process Positive Regulation Of MRNA Splicing, Via Spliceosome Chaperone Cofactor-dependent Protein Refolding Regulation Of Cell Cycle Membrane Organization Regulation Of Protein Complex Stability Chaperone-mediated Autophagy Late Endosomal Microautophagy Protein Targeting To Lysosome Involved In Chaperone-mediated Autophagy Chaperone-mediated Protein Transport Involved In Chaperone-mediated Autophagy Clathrin Coat Disassembly Regulation Of Postsynapse Organization Regulation Of Cellular Response To Heat Negative Regulation Of Supramolecular Fiber Organization Regulation Of Protein Import Chaperone-mediated Autophagy Translocation Complex Disassembly Slow Axonal Transport	Protein Sumoylation Cellular Response To Oxidative Stress Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of DNA Binding Negative Regulation Of DNA Binding Negative Regulation Of Transcription, DNA-templated Regulation Of Protein Localization To Nucleus
Pathways		Regulation of HSF1-mediated heat shock response HSP90 chaperone cycle for steroid hormone receptors (SHR) Attenuation phase HSF1-dependent transactivation Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis CHL1 interactions AUF1 (hnRNP D0) binds and destabilizes mRNA Interleukin-4 and Interleukin-13 signaling Neutrophil degranulation mRNA Splicing - Major Pathway Clathrin-mediated endocytosis Protein methylation GABA synthesis, release, reuptake and degradation Lipophagy Chaperone Mediated Autophagy Late endosomal microautophagy
Drugs		Dasatinib (2R,3R,4S,5R)-2-[6-amino-8-[(3,4-dichlorophenyl)methylamino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol Copper Artenimol
Diseases
GWAS		Mean corpuscular hemoglobin ( 32888494) Mean corpuscular hemoglobin concentration ( 29403010 32888494) Postoperative acute renal failure after cardiac surgery ( 30678657) Red cell distribution width ( 32888494)	Dupuytren's disease ( 28886342)
Interacting Genes		91 interacting genes: ABI1 AIPL1 ALDOB APOB ATM BAG1 BAG2 BAG3 BAG4 BAG6 BRCA1 CAPZA1 CAPZB CCT3 CD40 CDKN2A CITED1 CLTA COL7A1 CXCR4 CYCS DNAJA1 DNAJA3 DNAJB1 DPP3 DYNLL1 EGFR ENO1 ERBB3 ERH ESR1 FANCC FBP1 GAK GCH1 GOT2 H3C1 HDAC10 HDAC3 HGS HLTF HSF1 HSP90AA1 HSPA1A HSPBP1 HSPH1 HTN3 HTT IL32 JAK2 JUN LALBA LINC01554 MAPK8 MAPT METTL21A NMI NOA1 PHC1 PPID PTEN PTPRF RAF1 RB1 REL RGS2 SGTA SIRPA SP1 SRRT ST13 STAT1 STIP1 STMN1 STUB1 SUMO2 SUMO4 TADA3 TCAP TCERG1 TGM2 TM4SF1 TNFRSF1A TRIM38 TSSK6 TTC1 UBC UCHL1 VHL YWHAG YWHAQ	75 interacting genes: ACADM ACO2 ACTG1 ALDOA ARHGDIA ATP5F1B CALR CAT CCT2 CCT5 CCT6A CCT7 CLIC1 DNAJA1 DNAJB11 EIF3I ENO1 ENO2 FOS G6PD GAPDH GMPS GSTP1 HNRNPD HNRNPF HNRNPH1 HNRNPL HSPA1B HSPA5 HSPA8 HSPA9 HSPD1 IDH1 IDH3A IMPDH2 JUN LDHB LMNA LMNB1 MRPS22 NFKBIA NR3C1 PA2G4 PAFAH1B3 PDIA3 PDIA6 PGK1 PHB PHGDH PITHD1 PPA1 PRDX2 PRDX3 PRDX4 PRDX6 PRPS1 PSMC2 RACK1 RPSA SF3B4 SPINT2 STAT1 STAT3 STIP1 STOML2 STRAP TFAP2A TOP2A TPM3 TUBA1C TXNL1 UBE2V1 VCP VDAC1 ZPR1
Entrez ID		3312	387082
HPRD ID		07205	10584
Ensembl ID		ENSG00000109971	ENSG00000177688
Uniprot IDs		P11142 Q53HF2 V9HW22	Q6EEV6
PDB IDs		3AGY 3AGZ 3ESK 3FZF 3FZH 3FZK 3FZL 3FZM 3LDQ 3M3Z 4H5N 4H5R 4H5T 4H5V 4H5W 4HWI 4KBQ 5AQF 5AQG 5AQH 5AQI 5AQJ 5AQK 5AQL 5AQM 5AQN 5AQO 5AQP 5AQQ 5AQR 5AQS 5AQT 5AQU 5AQV 6B1I 6B1M 6B1N
Enriched GO Terms of Interacting Partners?
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