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CCN2 and TGFB2
Data Source:
HPRD
(in vivo)
CCN2
TGFB2
Description
cellular communication network factor 2
transforming growth factor beta 2
Image
No pdb structure
GO Annotations
Cellular Component
Extracellular Region
Extracellular Space
Cis-Golgi Network
Cytosol
Plasma Membrane
Cell Cortex
Extracellular Matrix
Perinuclear Region Of Cytoplasm
Collagen-containing Extracellular Matrix
Extracellular Region
Extracellular Space
Axon
Platelet Alpha Granule Lumen
Neuronal Cell Body
Collagen-containing Extracellular Matrix
Molecular Function
Fibronectin Binding
Integrin Binding
Protein Binding
Insulin-like Growth Factor Binding
Protein C-terminus Binding
Growth Factor Activity
Heparin Binding
Amyloid-beta Binding
Signaling Receptor Binding
Type II Transforming Growth Factor Beta Receptor Binding
Cytokine Activity
Transforming Growth Factor Beta Receptor Binding
Protein Binding
Growth Factor Activity
Type III Transforming Growth Factor Beta Receptor Binding
Protein Homodimerization Activity
Biological Process
Cartilage Condensation
Ossification
Angiogenesis
Tissue Homeostasis
Positive Regulation Of Protein Phosphorylation
Transcription Initiation From RNA Polymerase II Promoter
Cell Adhesion
Cell-matrix Adhesion
Signal Transduction
Integrin-mediated Signaling Pathway
Aging
Positive Regulation Of Cell Population Proliferation
Fibroblast Growth Factor Receptor Signaling Pathway
Epidermis Development
Response To Wounding
Response To Glucose
Positive Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Positive Regulation Of Cell Death
Cell Migration
Cell Differentiation
Lung Development
Regulation Of Chondrocyte Differentiation
Response To Estradiol
Positive Regulation Of Collagen Biosynthetic Process
Response To Anoxia
Intracellular Signal Transduction
Chondrocyte Proliferation
Response To Amino Acid
Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Response To Peptide Hormone
Positive Regulation Of Cell Differentiation
Positive Regulation Of JNK Cascade
Positive Regulation Of Cell Activation
Response To Mineralocorticoid
Positive Regulation Of Stress Fiber Assembly
Cytosolic Calcium Ion Transport
Positive Regulation Of Cardiac Muscle Contraction
Negative Regulation Of Cell Death
Extracellular Matrix Constituent Secretion
Positive Regulation Of G0 To G1 Transition
Positive Regulation Of ERK1 And ERK2 Cascade
Response To Fatty Acid
DNA Biosynthetic Process
Reactive Oxygen Species Metabolic Process
Cell Morphogenesis
Skeletal System Development
Eye Development
Response To Hypoxia
Kidney Development
Epithelial To Mesenchymal Transition
Neural Tube Closure
Hair Follicle Development
Platelet Degranulation
Heart Morphogenesis
Outflow Tract Septum Morphogenesis
Membranous Septum Morphogenesis
Heart Valve Morphogenesis
Atrioventricular Valve Morphogenesis
Pulmonary Valve Morphogenesis
Endocardial Cushion Morphogenesis
Cardiac Right Ventricle Morphogenesis
Ventricular Trabecula Myocardium Morphogenesis
Endocardial Cushion Fusion
Atrial Septum Primum Morphogenesis
Neural Retina Development
Protein Phosphorylation
Cell Cycle Arrest
Transforming Growth Factor Beta Receptor Signaling Pathway
Salivary Gland Morphogenesis
Heart Development
Cell Death
Positive Regulation Of Cell Population Proliferation
Negative Regulation Of Cell Population Proliferation
Glial Cell Migration
Male Gonad Development
Response To Wounding
Embryo Development Ending In Birth Or Egg Hatching
Cardioblast Differentiation
Negative Regulation Of Gene Expression
Positive Regulation Of Epithelial Cell Migration
Negative Regulation Of Alkaline Phosphatase Activity
Positive Regulation Of Epithelial To Mesenchymal Transition
Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation
Negative Regulation Of Macrophage Cytokine Production
Positive Regulation Of Phosphatidylinositol 3-kinase Signaling
Cell Migration
Negative Regulation Of Angiogenesis
Hemopoiesis
Collagen Fibril Organization
Positive Regulation Of Cell Growth
Negative Regulation Of Cell Growth
Embryonic Limb Morphogenesis
BMP Signaling Pathway
Neutrophil Chemotaxis
Hair Follicle Morphogenesis
Activation Of Protein Kinase Activity
Response To Progesterone
Positive Regulation Of Stress-activated MAPK Cascade
Regulation Of Transforming Growth Factor Beta2 Production
Positive Regulation Of Cell Adhesion Mediated By Integrin
Ascending Aorta Morphogenesis
Wound Healing
Regulation Of Cell Population Proliferation
Dopamine Biosynthetic Process
Odontogenesis
Response To Drug
Uterine Wall Breakdown
Positive Regulation Of Neuron Apoptotic Process
Cell-cell Junction Organization
Positive Regulation Of Integrin Biosynthetic Process
Positive Regulation Of Notch Signaling Pathway
Positive Regulation Of Ossification
Positive Regulation Of Cell Cycle
Positive Regulation Of Heart Contraction
Negative Regulation Of Ras Protein Signal Transduction
Somatic Stem Cell Division
Embryonic Digestive Tract Development
Neuron Development
Generation Of Neurons
Inner Ear Development
Negative Regulation Of Epithelial Cell Proliferation
Positive Regulation Of Protein Secretion
Positive Regulation Of Immune Response
Positive Regulation Of Cell Division
Regulation Of Timing Of Catagen
Positive Regulation Of Timing Of Catagen
Positive Regulation Of Cardioblast Differentiation
Cardiac Muscle Cell Proliferation
Uterus Development
Cardiac Epithelial To Mesenchymal Transition
Pathway-restricted SMAD Protein Phosphorylation
SMAD Protein Signal Transduction
Ventricular Septum Morphogenesis
Atrial Septum Morphogenesis
Pharyngeal Arch Artery Morphogenesis
Secondary Palate Development
Extrinsic Apoptotic Signaling Pathway
Regulation Of Apoptotic Process Involved In Outflow Tract Morphogenesis
Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II
Regulation Of Complement-dependent Cytotoxicity
Substantia Propria Of Cornea Development
Cranial Skeletal System Development
Negative Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation
Positive Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation
Pathways
YAP1- and WWTR1 (TAZ)-stimulated gene expression
RUNX3 regulates YAP1-mediated transcription
Platelet degranulation
Molecules associated with elastic fibres
ECM proteoglycans
Drugs
Diseases
Graft-versus-host disease
Allograft rejection
GWAS
Acne (severe) (
24927181
30542056
)
Body fat distribution (leg fat ratio) (
30664634
)
Body fat distribution (trunk fat ratio) (
30664634
)
Bone mineral density (hip) (
30172743
)
Central corneal thickness (
32528159
29760442
)
Chronic obstructive pulmonary disease (
28166215
30804561
)
Chronic obstructive pulmonary disease (severe) (
24621683
)
Diastolic blood pressure (
30224653
)
Diffusing capacity of carbon monoxide (
30694715
)
Emphysema imaging phenotypes (
26030696
)
FEV1 (
30804560
)
Gemcitabine-induced early high-grade neutropenia in pancreatic cancer (
30889042
)
Heel bone mineral density (
30598549
)
Height (
20881960
25282103
25429064
31562340
)
Hip circumference adjusted for BMI (
25673412
)
Hip minimal joint space width (
27701424
)
Intraocular pressure (
29617998
)
Local histogram emphysema pattern (
25006744
)
Lung function (FEV1/FVC) (
30804560
)
Lung function (FVC) (
30804560
)
Peak expiratory flow (
30804560
)
Post bronchodilator FEV1 (
26634245
)
Post bronchodilator FEV1/FVC ratio (
26634245
)
Pulmonary function (
21946350
)
Refractive error (
32231278
)
Rosacea symptom severity (
29771307
)
Systolic blood pressure (
30578418
)
Vertical cup-disc ratio (adjusted for vertical disc diameter) (
31959993
)
Vertical cup-disc ratio (multi-trait analysis) (
31959993
)
Waist circumference adjusted for BMI (adjusted for smoking behaviour) (
28443625
)
Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) (
28448500
)
Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) (
28443625
)
Waist circumference adjusted for BMI in active individuals (
28448500
)
Waist circumference adjusted for BMI in non-smokers (
28443625
)
Waist circumference adjusted for body mass index (
25673412
28448500
)
Interacting Genes
13 interacting genes:
ACTB
AP3D1
CCN3
ERBB4
FBLN1
HSPG2
LIMS1
LRP1
MTDH
TGFB1
TGFB2
TGFB3
VEGFA
15 interacting genes:
APP
BMP2
CCN2
DCN
ENG
FMOD
LTBP3
PZP
TGFB1
TGFB3
TGFBR1
TGFBR2
TGFBR3
VASN
VTN
Entrez ID
1490
7042
HPRD ID
00412
01828
Ensembl ID
ENSG00000118523
ENSG00000092969
Uniprot IDs
P29279
Q5M8T4
P61812
Q59EG9
PDB IDs
1TFG
2TGI
4KXZ
5TX4
5TY4
6I9J
Enriched GO Terms of Interacting Partners
?
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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