WIPF2 and PFN1

Data Source:
HPRD (in vitro, in vivo)

		WIPF2	PFN1
Description		WAS/WASL interacting protein family member 2	profilin 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytosol Actin Filament Plasma Membrane	Nucleus Cytoplasm Cytosol Cytoskeleton Focal Adhesion Cell Cortex Membrane Extracellular Exosome Blood Microparticle
	Molecular Function	Actin Binding Protein Binding	Adenyl-nucleotide Exchange Factor Activity Phosphotyrosine Residue Binding RNA Binding Actin Binding Actin Monomer Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Cadherin Binding Proline-rich Region Binding
	Biological Process	Actin Filament-based Movement Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis	Positive Regulation Of Epithelial Cell Migration Actin Cytoskeleton Organization Regulation Of Actin Filament Polymerization Negative Regulation Of Actin Filament Polymerization Positive Regulation Of Actin Filament Polymerization Negative Regulation Of Actin Filament Bundle Assembly Positive Regulation Of Actin Filament Bundle Assembly Positive Regulation Of ATPase Activity Protein Stabilization Negative Regulation Of Stress Fiber Assembly Wnt Signaling Pathway, Planar Cell Polarity Pathway Positive Regulation Of Ruffle Assembly
Pathways		Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis	Platelet degranulation Signaling by ROBO receptors PCP/CE pathway RHO GTPases Activate Formins RHO GTPases Activate Formins
Drugs			7-HYDROXY-4-METHYL-3-(2-HYDROXY-ETHYL)COUMARIN Artenimol
Diseases
GWAS		Asthma ( 31619474) Blond vs. brown/black hair color ( 30531825) Household income (MTAG) ( 31844048) PR interval in Tripanosoma cruzi seropositivity ( 24324551)	Mean platelet volume ( 32888494)
Interacting Genes		12 interacting genes: APBB1 DNMBP GRB2 ITSN2 NCK2 PFN1 SORBS3 TCERG1 TVP23A WAS WASL WWOX	33 interacting genes: ACTA1 ACTB AFDN APBB1IP CMA1 CRMP1 DBN1 DLG5 DNM2 ENAH ERG28 FMNL1 GPHN LRIF1 MYPOP NCK1 PIK3R1 RAD51 RHOQ SIRPA SRPK1 STUB1 TLE1 TRAF6 TRIM15 UNC119 VASP VIPR1 WASF1 WASL WIPF2 XPO6 YWHAQ
Entrez ID		147179	5216
HPRD ID		18304	01452
Ensembl ID		ENSG00000171475	ENSG00000108518
Uniprot IDs		Q8TF74	P07737
PDB IDs			1AWI 1CF0 1CJF 1FIK 1FIL 1PFL 2PAV 2PBD 3CHW 4X1L 4X1M 4X25 6NAS 6NBE 6NBW
Enriched GO Terms of Interacting Partners?
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