PFN1 and MYPOP

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		PFN1	MYPOP
Description		profilin 1	Myb related transcription factor, partner of profilin
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Cytoskeleton Focal Adhesion Cell Cortex Membrane Extracellular Exosome Blood Microparticle	Nucleus
	Molecular Function	Adenyl-nucleotide Exchange Factor Activity Phosphotyrosine Residue Binding RNA Binding Actin Binding Actin Monomer Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Cadherin Binding Proline-rich Region Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Protein Binding Identical Protein Binding
	Biological Process	Positive Regulation Of Epithelial Cell Migration Actin Cytoskeleton Organization Regulation Of Actin Filament Polymerization Negative Regulation Of Actin Filament Polymerization Positive Regulation Of Actin Filament Polymerization Negative Regulation Of Actin Filament Bundle Assembly Positive Regulation Of Actin Filament Bundle Assembly Positive Regulation Of ATPase Activity Protein Stabilization Negative Regulation Of Stress Fiber Assembly Wnt Signaling Pathway, Planar Cell Polarity Pathway Positive Regulation Of Ruffle Assembly	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II
Pathways		Platelet degranulation Signaling by ROBO receptors PCP/CE pathway RHO GTPases Activate Formins RHO GTPases Activate Formins
Drugs		7-HYDROXY-4-METHYL-3-(2-HYDROXY-ETHYL)COUMARIN Artenimol
Diseases
GWAS		Mean platelet volume ( 32888494)	Asthma ( 31959851)
Interacting Genes		33 interacting genes: ACTA1 ACTB AFDN APBB1IP CMA1 CRMP1 DBN1 DLG5 DNM2 ENAH ERG28 FMNL1 GPHN LRIF1 MYPOP NCK1 PIK3R1 RAD51 RHOQ SIRPA SRPK1 STUB1 TLE1 TRAF6 TRIM15 UNC119 VASP VIPR1 WASF1 WASL WIPF2 XPO6 YWHAQ	42 interacting genes: AKAP8L BAG4 BBC3 CARD10 CHIC2 CIB4 CYSRT1 FHL3 HNRNPH1 HNRNPK HOXA1 KHDRBS3 KIFAP3 KRT40 KRTAP1-3 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP12-2 KRTAP19-5 KRTAP19-6 KRTAP3-1 KRTAP5-6 MDFI MTUS2 NBPF19 NCK2 NECAB2 NOTCH2NLA PFN1 PFN2 PRDM14 PRR3 RBM3 RBMX RBMY1A1 RBPMS2 SAT1 SYNCRIP TGM1 TNS2 TRA2B
Entrez ID		5216	339344
HPRD ID		01452	17352
Ensembl ID		ENSG00000108518	ENSG00000176182
Uniprot IDs		P07737	Q86VE0
PDB IDs		1AWI 1CF0 1CJF 1FIK 1FIL 1PFL 2PAV 2PBD 3CHW 4X1L 4X1M 4X25 6NAS 6NBE 6NBW
Enriched GO Terms of Interacting Partners?
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