NCAN and L1CAM

Data Source:
BioGRID (pull down)
HPRD (in vivo)

		NCAN	L1CAM
Description		neurocan	L1 cell adhesion molecule
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Golgi Lumen Extracellular Matrix Lysosomal Lumen	Plasma Membrane Focal Adhesion Cell Surface Integral Component Of Membrane Axon Dendrite Neuronal Cell Body Axonal Growth Cone Collagen-containing Extracellular Matrix
	Molecular Function	Calcium Ion Binding Hyaluronic Acid Binding Carbohydrate Binding	Protein Binding Axon Guidance Receptor Activity Protein Domain Specific Binding
	Biological Process	Skeletal System Development Cell Adhesion Central Nervous System Development Extracellular Matrix Organization Chondroitin Sulfate Biosynthetic Process Chondroitin Sulfate Catabolic Process Dermatan Sulfate Biosynthetic Process	Chemotaxis Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Cell-matrix Adhesion Nervous System Development Axon Guidance Cell Migration Neuron Projection Development Positive Regulation Of Axon Extension Synapse Organization Leukocyte Migration Axon Development
Pathways		A tetrasaccharide linker sequence is required for GAG synthesis Chondroitin sulfate biosynthesis Dermatan sulfate biosynthesis CS/DS degradation ECM proteoglycans Defective B4GALT7 causes EDS, progeroid type Defective B3GAT3 causes JDSSDHD Defective CHST3 causes SEDCJD Defective CHST14 causes EDS, musculocontractural type Defective CHSY1 causes TPBS L1CAM interactions NCAM1 interactions Defective B3GALT6 causes EDSP2 and SEMDJL1	Basigin interactions L1CAM interactions L1CAM interactions Recycling pathway of L1 Recycling pathway of L1 Interaction between L1 and Ankyrins Interaction between L1 and Ankyrins Signal transduction by L1
Drugs		Beta-D-Glucose Thiodigalactoside Hyaluronic acid	Ethanol
Diseases			Hereditary spastic paraplegia (SPG) Syndromic X-linked mental retardation with epilepsy or seizures, including: West syndrome (WS); Partington syndrome (PRTS); Proud syndrome (ACCAG); XMR and epilepsy (XMRE); MRXHF1; XMR OPHN1-related (MRXSO) ; XELBD; XMR, Christianson type (MRXSC); Creatine deficiency syndrome (XL-CDS); Renpenning syndrome (RENS1); Epilepsy and mental retardation limited to females (EFMR); Periventricular nodular heterotopia (PVNH); Hydrocephalus (XLH); XMR, JARID1C related (MRXSJ); Boerjeson-Forssman syndrome (BFLS); CK syndrome (CKS) L1 syndrome, including: ; X-linked hydrocephalus; MASA syndrome; X-linked complicated spastic paraplegia type I ; X-linked partial agenesis of corpus callosum
GWAS		Bipolar disorder ( 24618891 31043756 21353194) Bipolar I disorder ( 31043756) Bipolar II disorder ( 31043756) Brain morphology (MOSTest) ( 32665545) C-reactive protein levels or LDL-cholesterol levels (pleiotropy) ( 27286809) C-reactive protein levels or total cholesterol levels (pleiotropy) ( 27286809) Cholesterol, total ( 19060911 26780889) LDL cholesterol ( 18193043 19060906 19060911 26780889) Nonalcoholic fatty liver disease ( 29385134) Plateletcrit ( 32888494) Refractive error ( 32231278) Schizophrenia ( 25056061 29483656 23974872) Triglycerides ( 18193043 19060906 19060911)
Interacting Genes		8 interacting genes: CNTN2 HMGB1 L1CAM NCAM1 PTN PTPRF TNC TNR	24 interacting genes: ANK1 ANK2 CNTN1 CNTN2 CSNK2A1 EZR FGFR1 ITGA5 ITGAV LINC00839 MSN NCAM1 NCAN NRP1 NRP2 NUMB PEA15 PLXNA1 PLXNB1 PRNP RANBP9 RDX RPS6KA1 RPS6KA2
Entrez ID		1463	3897
HPRD ID		02897	02394
Ensembl ID		ENSG00000130287	ENSG00000198910
Uniprot IDs		A0A024R7M3 O14594 Q4LE67	P32004
PDB IDs
Enriched GO Terms of Interacting Partners?
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