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DYDC1 and PIK3R2
Data Source:
BioGRID
(two hybrid)
DYDC1
PIK3R2
Description
DPY30 domain containing 1
phosphoinositide-3-kinase regulatory subunit 2
Image
No pdb structure
GO Annotations
Cellular Component
Chromosome, Telomeric Region
MLL3/4 Complex
Set1C/COMPASS Complex
Nucleus
Cytosol
Phosphatidylinositol 3-kinase Complex
Molecular Function
Protein Binding
Phosphotyrosine Residue Binding
Protein Binding
Protein Phosphatase Binding
Receptor Tyrosine Kinase Binding
1-phosphatidylinositol-3-kinase Regulator Activity
Protein Heterodimerization Activity
Biological Process
Chromatin Silencing At Telomere
Histone H3-K4 Methylation
Cellular Glucose Homeostasis
Phosphatidylinositol Biosynthetic Process
Insulin Receptor Signaling Pathway
Regulation Of Autophagy
Phosphatidylinositol 3-kinase Signaling
Protein Transport
Cellular Response To Insulin Stimulus
Response To Endoplasmic Reticulum Stress
Fc-epsilon Receptor Signaling Pathway
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Positive Regulation Of Protein Import Into Nucleus
Negative Regulation Of MAPK Cascade
Regulation Of Phosphatidylinositol 3-kinase Activity
Positive Regulation Of Transcription By RNA Polymerase II
Phosphatidylinositol Phosphorylation
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Phosphatidylinositol-mediated Signaling
T Cell Receptor Signaling Pathway
Leukocyte Migration
Regulation Of Small GTPase Mediated Signal Transduction
Positive Regulation Of Protein Kinase B Signaling
Pathways
PI3K Cascade
IRS-mediated signalling
GPVI-mediated activation cascade
PIP3 activates AKT signaling
Interleukin-7 signaling
Interleukin-7 signaling
Signaling by SCF-KIT
Synthesis of PIPs at the plasma membrane
Downstream signal transduction
Rho GTPase cycle
PI3K/AKT activation
Downstream TCR signaling
Role of phospholipids in phagocytosis
Tie2 Signaling
Constitutive Signaling by Aberrant PI3K in Cancer
DAP12 signaling
Role of LAT2/NTAL/LAB on calcium mobilization
Nephrin family interactions
Costimulation by the CD28 family
CD28 dependent PI3K/Akt signaling
G alpha (q) signalling events
VEGFA-VEGFR2 Pathway
VEGFA-VEGFR2 Pathway
Interleukin-3, Interleukin-5 and GM-CSF signaling
RAF/MAP kinase cascade
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
RET signaling
Extra-nuclear estrogen signaling
Interleukin receptor SHC signaling
Regulation of signaling by CBL
Regulation of signaling by CBL
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants
Signaling by PDGFRA extracellular domain mutants
Drugs
Isoprenaline
SF1126
Diseases
GWAS
Estimated glomerular filtration rate (
31451708
)
Basophil count (
32888494
)
Basophil percentage of white cells (
32888494
)
Mental health study participation (completed survey) (
31263887
)
Interacting Genes
33 interacting genes:
ARNT2
CCHCR1
CCNC
CEP57L1
DPY30
ENKD1
HDAC4
HGS
KRT75
LMO2
LNX1
MID2
MOS
NME5
PDZD4
PIK3R2
PKN1
POU6F2
PPP2R5D
PSMA1
TCHP
TEAD4
TFPT
TLE5
TSGA10IP
TXLNB
TXNDC9
USHBP1
USP2
VPS37C
VPS9D1
WAC
ZGPAT
59 interacting genes:
APP
APPL1
AR
ARRB1
AXL
CBL
CD28
CRK
CRKL
CSF1R
DYDC1
EGF
EGFR
ENKUR
EPHA2
ERBB2
ERBB3
ERBB4
FBXL2
FGFR1
FYN
GAB1
GHR
GOLGA2
GRB2
GRN
HCK
IGF1R
IKZF3
IRS1
IRS2
KIT
KRAS
KRT15
KRT20
KRT38
LAMB2
LMNA
LTBP3
MET
MRFAP1L1
PDGFRB
PIK3CD
RINT1
SEPTIN2
SHC1
SOCS1
SOCS6
SOCS7
SOS1
STAB1
STAT3
SYK
TEC
TGFBR1
TGFBR2
TRIM23
WASF3
YWHAB
Entrez ID
143241
5296
HPRD ID
14062
04404
Ensembl ID
ENSG00000170788
ENSG00000105647
Uniprot IDs
Q8WWB3
O00459
PDB IDs
2KT1
2XS6
3MTT
3O5Z
6OX7
6U28
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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