MIB2 and PUSL1

Data Source:
BioGRID (proximity labelling technology)

		MIB2	PUSL1
Description		MIB E3 ubiquitin protein ligase 2	pseudouridine synthase like 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Cytoplasm Early Endosome Cytosol	Intracellular Membrane-bounded Organelle
	Molecular Function	Actin Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ubiquitin Protein Ligase Activity	RNA Binding Pseudouridine Synthase Activity
	Biological Process	Protein Polyubiquitination Notch Signaling Pathway Protein Ubiquitination Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling	TRNA Pseudouridine Synthesis
Pathways		Activated NOTCH1 Transmits Signal to the Nucleus Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants NOTCH2 Activation and Transmission of Signal to the Nucleus NOTCH3 Activation and Transmission of Signal to the Nucleus Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Body mass index ( 26426971) Height ( 31562340) Iris color (a* coordinate) ( 30895295) Iris color (b* coordinate) ( 30895295)	Inflammatory bowel disease ( 28067908) Ulcerative colitis ( 28067908)
Interacting Genes		10 interacting genes: ACTA1 ACTC1 BCL10 GRIN2B JAG2 SRPK2 TBK1 UBE2D2 UBE2N UBE2U	2 interacting genes: APP FBXO7
Entrez ID		142678	126789
HPRD ID		15905	08301
Ensembl ID		ENSG00000197530	ENSG00000169972
Uniprot IDs		Q96AX9	Q8N0Z8
PDB IDs
Enriched GO Terms of Interacting Partners?
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