ASB9 and EXOSC1

Data Source:
BioGRID (two hybrid)

		ASB9	EXOSC1
Description		ankyrin repeat and SOCS box containing 9	exosome component 1
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GO Annotations	Cellular Component	Mitochondrion Cytosol	Nuclear Exosome (RNase Complex) Exosome (RNase Complex) Nucleoplasm Nucleolus Cytoplasm Cytosol
	Molecular Function	Protein Binding	RNA Binding Exoribonuclease Activity Protein Binding
	Biological Process	Protein Ubiquitination Intracellular Signal Transduction Post-translational Protein Modification Positive Regulation Of Protein Catabolic Process	RRNA Processing Regulation Of MRNA Stability Exonucleolytic Catabolism Of Deadenylated MRNA RNA Phosphodiester Bond Hydrolysis, Exonucleolytic
Pathways		Neddylation Antigen processing: Ubiquitination & Proteasome degradation	ATF4 activates genes in response to endoplasmic reticulum stress mRNA decay by 3' to 5' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA Major pathway of rRNA processing in the nucleolus and cytosol
Drugs
Diseases
GWAS		Metabolite levels ( 23823483)	Blood protein levels ( 30072576) Early spontaneous preterm birth ( 31194736) Spontaneous preterm birth with premature rupture of membranes ( 31194736)
Interacting Genes		12 interacting genes: ACTN3 ASB13 CKB CKM CKMT1A CKMT1B EXOSC1 HIF1AN LCK PLCG2 RELA UBE2D1	34 interacting genes: A2M APP ASB9 CDC37 DDIT4L DMRTB1 ECSIT EXOC6 EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC8 EXOSC9 FHL3 KCTD1 LNX1 LSM3 MAST1 MPHOSPH6 NOS3 NUP160 PAK5 PTEN RBPMS REL RNF32 SH3GLB2 TCF4 TEX11 UPF2 XRN1 ZNF143 ZNF76
Entrez ID		140462	51013
HPRD ID		06452	16223
Ensembl ID		ENSG00000102048	ENSG00000171311
Uniprot IDs		A0A024RBW2 A0A024RBW7 A0A024RBZ4 Q96DX5	B1AMU3 Q9Y3B2
PDB IDs		3D9H 3ZKJ 3ZNG 6V9H	2NN6 6D6Q 6D6R 6H25
Enriched GO Terms of Interacting Partners?
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