CLDN4 and ICAM3

Data Source:
BioGRID (two hybrid)

		CLDN4	ICAM3
Description		claudin 4	intercellular adhesion molecule 3
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GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction Bicellular Tight Junction Basal Plasma Membrane Apical Plasma Membrane Apicolateral Plasma Membrane Lateral Plasma Membrane Chloride Channel Complex Tight Junction	Plasma Membrane Integral Component Of Plasma Membrane Extracellular Exosome
	Molecular Function	Transmembrane Signaling Receptor Activity Structural Molecule Activity Chloride Channel Activity Protein Binding Identical Protein Binding	Signaling Receptor Binding Integrin Binding Protein Binding
	Biological Process	Cell Adhesion Female Pregnancy Circadian Rhythm Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Regulation Of Cell Morphogenesis Positive Regulation Of Cell Migration Response To Progesterone Establishment Of Skin Barrier Renal Absorption Bicellular Tight Junction Assembly Positive Regulation Of Wound Healing Chloride Transmembrane Transport Positive Regulation Of Metallopeptidase Activity	Stimulatory C-type Lectin Receptor Signaling Pathway Phagocytosis Cell Adhesion Extracellular Matrix Organization Regulation Of Immune Response Cell-cell Adhesion
Pathways		Tight junction interactions	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Integrin cell surface interactions CD209 (DC-SIGN) signaling
Drugs
Diseases
GWAS			Crohn's disease ( 28067908 21102463) Inflammatory bowel disease ( 28067908) Rheumatoid arthritis ( 23143596) Rheumatoid arthritis (ACPA-positive) ( 23143596) Systemic lupus erythematosus or rheumatoid arthritis ( 27193031)
Interacting Genes		19 interacting genes: AQP6 ARL13B CLEC14A EPHA2 FAM209A FFAR2 GJA8 GOLM1 HSD17B13 ICAM3 MFSD14B SHBG SYT2 TJP1 TMEM237 TMEM52B TRIM59 TSPO2 WNK4	20 interacting genes: APP BRICD5 CD209 CLDN19 CLDN4 CLEC4M EDDM3B EZR ITGAD ITGAL ITGB2 MSN NINJ2 PRKCQ SEC22A SFTPC SMCO4 SMIM1 TSPO ZBTB16
Entrez ID		1364	3385
HPRD ID		04218	00889
Ensembl ID		ENSG00000189143	ENSG00000076662
Uniprot IDs		O14493 Q75L80	A0A024R7C1 K7ERN2 P32942
PDB IDs		5B2G	1T0P
Enriched GO Terms of Interacting Partners?
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