COPA and TMED2

Data Source:
HPRD (in vitro)

		COPA	TMED2
Description		COPI coat complex subunit alpha	transmembrane p24 trafficking protein 2
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GO Annotations	Cellular Component	Golgi Membrane Extracellular Space Cytoplasm Endoplasmic Reticulum Membrane Cytosol Membrane COPI Vesicle Coat Transport Vesicle Growth Cone Extracellular Exosome	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus ER To Golgi Transport Vesicle Membrane Integral Component Of Membrane Transport Vesicle COPII-coated ER To Golgi Transport Vesicle COPI-coated Vesicle COPI-coated Vesicle Membrane Golgi Cisterna Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Zymogen Granule Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Hormone Activity Structural Molecule Activity Protein Binding	Protein Binding
	Biological Process	Intracellular Protein Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Intra-Golgi Vesicle-mediated Transport Signal Transduction Pancreatic Juice Secretion	Neural Tube Closure Maternal Placenta Development Heart Looping Intracellular Protein Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Golgi Organization Positive Regulation Of Gene Expression Somite Rostral/caudal Axis Specification Negative Regulation Of GTPase Activity Multicellular Organism Growth Vesicle Cargo Loading Post-anal Tail Morphogenesis PERK-mediated Unfolded Protein Response COPI Coating Of Golgi Vesicle COPII Vesicle Coating Labyrinthine Layer Blood Vessel Development Protein Localization To Plasma Membrane Endoplasmic Reticulum Membrane Organization Negative Regulation Of Endoplasmic Reticulum Stress-induced EIF2 Alpha Phosphorylation Regulation Of SREBP Signaling Pathway
Pathways		COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic	Pre-NOTCH Processing in Golgi COPII-mediated vesicle transport Cargo concentration in the ER COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic
Drugs
Diseases
GWAS		Breast size ( 27182965)	Educational attainment ( 25201988) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		18 interacting genes: ARCN1 ARFGAP1 CDC42 COPB2 COPE DUX4 MTNR1B PDGFRB PTEN SACM1L SCYL1 SLC25A11 STX8 SUMO2 TMED10 TMED2 WBP1 WBP2	9 interacting genes: AKT2 ARF1 ARFGAP1 COPA GOLGA2 GORASP1 GORASP2 SEC23B TMED10
Entrez ID		1314	10959
HPRD ID		03564	17984
Ensembl ID		ENSG00000122218	ENSG00000086598
Uniprot IDs		P53621	Q15363 Q6FHT8
PDB IDs		6PBG 6TZT 6U3V	5AZW
Enriched GO Terms of Interacting Partners?
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